Original Research

Published on 29 Feb 2024

Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells

in Medicinal and Pharmaceutical Chemistry

Mohamed S. Nafie
Abdullah Mohammed Al-Majid
M. Ali
Abdulmajeed Abdullah Alayyaf
Matti Haukka
Sajda Ashraf
Zaheer Ul-Haq
Ayman El-Faham
Assem Barakat

Frontiers in Chemistry

doi 10.3389/fchem.2024.1364378

1,959 views
2 citations

Original Research

Published on 27 Feb 2024

Anti-ulcerative colitis effects of chemically characterized extracts from Calliandra haematocephala in acetic acid-induced ulcerative colitis

in Medicinal and Pharmaceutical Chemistry

Inaam Ur Rehman
Mohammad Saleem
Syed Atif Raza
Saher Bashir
Taha Muhammad
Shahzad Asghar
Muhammad Usman Qamar
Tawaf Ali Shah
Yousef A. Bin Jardan
Amare Bitew Mekonnen

Frontiers in Chemistry

doi 10.3389/fchem.2024.1291230

2,275 views
1 citation

Original Research

Published on 22 Feb 2024

Double cross-linked graphene oxide hydrogel for promoting healing of diabetic ulcers

in Medicinal and Pharmaceutical Chemistry

Wenxu Liu
Yunfang Yang
Meiying Li
Jingxin Mo

Frontiers in Chemistry

doi 10.3389/fchem.2024.1355646

2,049 views

Original Research

Published on 16 Feb 2024

Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches

in Medicinal and Pharmaceutical Chemistry

Syed Mohd Danish Rizvi
Ibrahim A. Almazni
Mamdoh S. Moawadh
Zeyad M. Alharbi
Nawal Helmi
Leena S. Alqahtani
Talib Hussain
Ahmed Alafnan
Afrasim Moin
AbdElmoneim O. Elkhalifa

Frontiers in Chemistry

doi 10.3389/fchem.2024.1352009

3,421 views
2 citations

Original Research

Published on 15 Feb 2024

Chemical profiling of volatile compounds of the essential oil of grey-leaved rockrose (Cistus albidus L.) and its antioxidant, anti-inflammatory, antibacterial, antifungal, and anticancer activity in vitro and in silico

in Medicinal and Pharmaceutical Chemistry

Amine Elbouzidi
Mohamed Taibi
Salah Laaraj
El Hassania Loukili
Mounir Haddou
Naoufal El Hachlafi
Hanae Naceiri Mrabti
Abdellah Baraich
Reda Bellaouchi
Abdeslam Asehraou

Frontiers in Chemistry

doi 10.3389/fchem.2024.1334028

5,249 views
12 citations

Correction

Published on 01 Feb 2024

Corrigendum: In vitro and in vivo evaluation of alginate hydrogel-based wound dressing loaded with green chemistry cerium oxide nanoparticles

in Medicinal and Pharmaceutical Chemistry

Ran Zhao
Chenyuyao Zhao
Yi Wan
Muhammad Majid
Syed Qamar Abbas
Yibing Wang

Frontiers in Chemistry

doi 10.3389/fchem.2024.1373205

1,647 views

Perspective

Published on 31 Jan 2024

BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery

in Medicinal and Pharmaceutical Chemistry

Andressa Francielli Bonjorno
Aline Renata Pavan
Guilherme F. S. Fernandes
Cauê Benito Scarim
Daniele Castagnolo
Jean Leandro Dos Santos

Frontiers in Chemistry

doi 10.3389/fchem.2024.1358539

4,919 views
2 citations

Original Research

Published on 31 Jan 2024

Characterization and comparative evaluation of wound healing potential of Ajugarin I and Ajuga bracteosa Wall. ex Benth

in Medicinal and Pharmaceutical Chemistry

Yusra Wasti
Durdana Muntaqua
Muhammad Majid
Iffat Naz
Aroosa Zafar
Safir Ullah Khan
Syeda Tayyaba Batool Kazmi
Tofeeq Ur Rehman
Nadeem Irshad
Humaira Fatima

Frontiers in Chemistry

doi 10.3389/fchem.2023.1325578

2,408 views
2 citations

Original Research

Published on 25 Jan 2024

Pb-214/Bi-214-TCMC-Trastuzumab inhibited growth of ovarian cancer in preclinical mouse models

in Medicinal and Pharmaceutical Chemistry

Abdullah Metebi
Nathan Kauffman
Lu Xu
Satyendra Kumar Singh
Chelsea Nayback
Jinda Fan
Nathan Johnson
John Diemer
Terry Grimm
Mike Zamiara

Frontiers in Chemistry

doi 10.3389/fchem.2023.1322773

3,938 views
1 citation

Review

Published on 22 Jan 2024

Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms

in Medicinal and Pharmaceutical Chemistry

Pengyu Zhao
Ye Tian
Yuefei Geng
Chenjuan Zeng
Xiuying Ma
Jie Kang
Lin Lu
Xin Zhang
Bo Tang
Funeng Geng

Frontiers in Chemistry

doi 10.3389/fchem.2024.1339364

3,798 views
3 citations

Original Research

Published on 22 Jan 2024

Integrating computational methods guided the discovery of phytochemicals as potential Pin1 inhibitors for cancer: pharmacophore modeling, molecular docking, MM-GBSA calculations and molecular dynamics studies

in Medicinal and Pharmaceutical Chemistry

Abdulrahim A. Alzain
Fatima A. Elbadwi
Tagyedeen H. Shoaib
Asmaa E. Sherif
Wadah Osman
Ahmed Ashour
Gamal A. Mohamed
Sabrin R. M. Ibrahim
Eun Joo Roh
Ahmed H. E. Hassan

Frontiers in Chemistry

doi 10.3389/fchem.2024.1339891

3,695 views
2 citations

Original Research

Published on 19 Jan 2024

Origanum majorana L. polyphenols: in vivo antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor

in Medicinal and Pharmaceutical Chemistry

Amal Amaghnouje
Mohamed Chebaibi
Saeed M. Aldossari
Hazem K. Ghneim
Fatima Ez-zahra Amrati
Imane Es-Safi
Francesca Di Cristo
Anna Calarco
Sanae Achour
Fabrizio Carta

Frontiers in Chemistry

doi 10.3389/fchem.2023.1257769

1,900 views

Original Research

Published on 19 Jan 2024

Chemical composition, antioxidant, and antimicrobial properties of Mentha subtomentella: in sight in vitro and in silico analysis

in Medicinal and Pharmaceutical Chemistry

Fatima Brahmi
Nour Eddine Bentouhami
Youssef Rbah
Amine Elbouzidi
Ouafae Mokhtari
Ahmad Mohammad Salamatullah
Samir Ibenmoussa
Mohammed Bourhia
Mohamed Addi
Abdeslam Asehraou

Frontiers in Chemistry

doi 10.3389/fchem.2023.1341704

2,262 views
1 citation

Original Research

Published on 16 Jan 2024

Elucidating the binding mechanism of SARS-CoV-2 NSP6-TBK1 and structure-based designing of phytocompounds inhibitors for instigating the host immune response

in Medicinal and Pharmaceutical Chemistry

Muhammad Suleman
Iqra Ishaq
Haji Khan
Safir Ullah khan
Rehana Masood
Norah A. Albekairi
Abdulrahman Alshammari
Sergio Crovella

Frontiers in Chemistry

doi 10.3389/fchem.2023.1346796

2,731 views
1 citation

Original Research

Published on 16 Jan 2024

ROS-dependent catalytic mechanism of melatonin metabolism and its application in the measurement of reactive oxygen

in Medicinal and Pharmaceutical Chemistry

Xiangge Tian
Xiaohui Kang
Fei Yan
Lei Feng
Xiaokui Huo
Houli Zhang
Yan Wang
Xia Lv
Xiaochi Ma
Jinsong Yuan

Frontiers in Chemistry

doi 10.3389/fchem.2023.1229199

1,411 views
2 citations

Original Research

Published on 11 Jan 2024

Versatile approach towards fully desymmetrized trehalose with a novel set of orthogonal protecting groups

in Medicinal and Pharmaceutical Chemistry

Tomáš Vašíček
Benjamin Arensmeyer
Alessandro Monti
Alla Zamyatina

Frontiers in Chemistry

doi 10.3389/fchem.2023.1332837

1,431 views

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Articles

Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells

Anti-ulcerative colitis effects of chemically characterized extracts from Calliandra haematocephala in acetic acid-induced ulcerative colitis

Double cross-linked graphene oxide hydrogel for promoting healing of diabetic ulcers

Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches

Chemical profiling of volatile compounds of the essential oil of grey-leaved rockrose (Cistus albidus L.) and its antioxidant, anti-inflammatory, antibacterial, antifungal, and anticancer activity in vitro and in silico

Corrigendum: In vitro and in vivo evaluation of alginate hydrogel-based wound dressing loaded with green chemistry cerium oxide nanoparticles

BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery

Characterization and comparative evaluation of wound healing potential of Ajugarin I and Ajuga bracteosa Wall. ex Benth

Pb-214/Bi-214-TCMC-Trastuzumab inhibited growth of ovarian cancer in preclinical mouse models

Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms

Integrating computational methods guided the discovery of phytochemicals as potential Pin1 inhibitors for cancer: pharmacophore modeling, molecular docking, MM-GBSA calculations and molecular dynamics studies

Origanum majorana L. polyphenols: in vivo antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor

Chemical composition, antioxidant, and antimicrobial properties of Mentha subtomentella: in sight in vitro and in silico analysis

Elucidating the binding mechanism of SARS-CoV-2 NSP6-TBK1 and structure-based designing of phytocompounds inhibitors for instigating the host immune response

ROS-dependent catalytic mechanism of melatonin metabolism and its application in the measurement of reactive oxygen

Versatile approach towards fully desymmetrized trehalose with a novel set of orthogonal protecting groups