Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 29 Jul 2024

ROS1 kinase inhibition reimagined: identifying repurposed drug via virtual screening and molecular dynamics simulations for cancer therapeutics

in Medicinal and Pharmaceutical Chemistry

Mohammed Alrouji
Sabina Yasmin
Fahad A Alhumaydhi
Sharaf E. Sharaf
Moyad Shahwan
Anas Shamsi

Frontiers in Chemistry

doi 10.3389/fchem.2024.1392650

1,307 views

Original Research

Published on 25 Jul 2024

Design, synthesis, and bioevaluation of diarylpyrimidine derivatives as novel microtubule destabilizers

in Medicinal and Pharmaceutical Chemistry

Yutao Xiu
Yujing Zhang
Shanbo Yang
Lingyu Shi
Dongming Xing
Chao Wang

Frontiers in Chemistry

doi 10.3389/fchem.2024.1447831

1,203 views

Original Research

Published on 22 Jul 2024

Synthesis and In vitro evaluation of bichalcones as novel anti-toxoplasma agents

in Medicinal and Pharmaceutical Chemistry

Flaminia Mazzone
Moritz K. T. Klischan
Julian Greb
Sander H. J. Smits
Jörg Pietruszka
Klaus Pfeffer

Frontiers in Chemistry

doi 10.3389/fchem.2024.1406307

1,564 views
2 citations

Original Research

Published on 17 Jul 2024

Cheminformatics-based identification of phosphorylated RET tyrosine kinase inhibitors for human cancer

in Medicinal and Pharmaceutical Chemistry

Md. Enamul Kabir Talukder
Md. Aktaruzzaman
Noimul Hasan Siddiquee
Sabrina Islam
Tanveer A. Wani
Hamad M. Alkahtani
Seema Zargar
Md. Obayed Raihan
Md. Mashiar Rahman
Sushil Pokhrel

Frontiers in Chemistry

doi 10.3389/fchem.2024.1407331

6,735 views
10 citations

Original Research

Published on 17 Jul 2024

BAR502/fibrate conjugates: synthesis, biological evaluation and metabolic profile

in Medicinal and Pharmaceutical Chemistry

Claudia Finamore
Simona De Marino
Chiara Cassiano
Giuliano Napolitano
Pasquale Rapacciuolo
Silvia Marchianò
Michele Biagioli
Rosalinda Roselli
Cristina Di Giorgio
Carmen Festa

Frontiers in Chemistry

doi 10.3389/fchem.2024.1425867

1,168 views

Original Research

Published on 16 Jul 2024

Extracellular vesicles enhance the in vivo antitumor effects of millettia species-derived compounds in chronic myelogenous leukemia therapy

in Medicinal and Pharmaceutical Chemistry

Zongzhou Xie
Xiaozhen Cheng
JianCang Mao
Yingqi Zhu
Le Li
Zhenxin Mei

Frontiers in Chemistry

doi 10.3389/fchem.2024.1425318

1,096 views
1 citation

Original Research

Published on 16 Jul 2024

Synthesis, characterization, and anti-cancer potential of novel p53-mediated Mdm2 and Pirh2 modulators: an integrated In silico and In vitro approach

in Medicinal and Pharmaceutical Chemistry

Sarfaraj Niazi
C. P. Kavana
H. K. Aishwarya
Chandan Dharmashekar
Anisha Jain
Tanveer A. Wani
Chandan Shivamallu
Madhusudan N. Purohit
Shiva Prasad Kollur

Frontiers in Chemistry

doi 10.3389/fchem.2024.1366370

1,675 views

Original Research

Published on 15 Jul 2024

Development of a versatile [68Ga]Ga-FAPI-46 automated synthesis suitable to multi-elutions of germanium-68/gallium-68 generators

in Medicinal and Pharmaceutical Chemistry

Louis-Paul Paty
Simon Degueldre
Claire Provost
Camille Schmitt
Laura Trump
Julien Fouque
Charles Vriamont
Frank Valla
Thibault Gendron
Olivier Madar

Frontiers in Chemistry

doi 10.3389/fchem.2024.1411312

2,326 views
1 citation

Original Research

Published on 12 Jul 2024

Comprehensive analysis of bioactive compounds in Crocus sativus stamens extracts by HPLC-DAD: investigating antidiabetic activity via in vitro, in vivo, and molecular docking simulation

in Medicinal and Pharmaceutical Chemistry

Samira Mamri
Nour Elhouda Daoudi
Abedellah Baraich
Sabir Ouahhoud
Amine Khoulati
Mohammed Choukri
Abdeslam Asehraou
Mohamed Bnouham
Bassem Jaouadi
Abdelkrim Abousalham

Frontiers in Chemistry

doi 10.3389/fchem.2024.1419120

2,258 views
1 citation

Original Research

Published on 09 Jul 2024

Pharmacophore-based virtual screening of commercial databases against β-secretase 1 for drug development against Alzheimer’s disease

in Medicinal and Pharmaceutical Chemistry

Xu Han
Kaibo Guo

Frontiers in Chemistry

doi 10.3389/fchem.2024.1412349

2,000 views

Review

Published on 05 Jul 2024

Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects

in Medicinal and Pharmaceutical Chemistry

Roman P. Terekhov
Anastasiya D. Savina
Denis I. Pankov
Maria D. Korochkina
Amir Taldaev
Liubov M. Yakubovich
Sergey P. Zavadskiy
Anastasiya K. Zhevlakova
Irina A. Selivanova

Frontiers in Chemistry

doi 10.3389/fchem.2024.1439167

2,170 views
3 citations

Original Research

Published on 04 Jul 2024

The chemical composition and the preservative, antimicrobial, and antioxidant effects of Thymus broussonetii Boiss. essential oil: an in vitro and in silico approach

in Medicinal and Pharmaceutical Chemistry

Smahane Boukhira
Fatima Ez-Zahra Amrati
Mohamed Chebaibi
Andriy Grafov
Ramzi A. Mothana
Hanan M. Al-Yousef
Dalila Bousta

Frontiers in Chemistry

doi 10.3389/fchem.2024.1402310

3,113 views
1 citation

Original Research

Published on 03 Jul 2024

Discovery and prospects of new heterocyclic Isatin-hydrazide derivative with a novel role as estrogen receptor α degrader in breast cancer cells

in Medicinal and Pharmaceutical Chemistry

Muhammad Nouman Arif
Sadia Sarwar
Farhat Firdous
Rahman Shah Zaib Saleem
Humaira Nadeem
Abir Abdullah Alamro
Amani Ahmad Alghamdi
Atekah Hazza Alshammari
Omer Farooq
Rashid Ali Khan

Frontiers in Chemistry

doi 10.3389/fchem.2024.1424637

3,861 views
3 citations

Review

Published on 02 Jul 2024

Research progress of Gastrodia elata Blume polysaccharides: a review of chemical structures and biological activities

in Medicinal and Pharmaceutical Chemistry

Liu Yang
Shi-Hui Qin
Cheng-Ting Zi

Frontiers in Chemistry

doi 10.3389/fchem.2024.1395222

2,499 views
3 citations

Original Research

Published on 26 Jun 2024

Design, synthesis, and evaluation of 1,4-benzothiazine-3-one containing bisamide derivatives as dual inhibitors of Staphylococcus aureus with plausible application in a urinary catheter

in Medicinal and Pharmaceutical Chemistry

Kaushal Naithani
Arka Das
Mamta Ushare
Subham Nath
Rashmita Biswas
Anirban Kundu
Kazi Tawsif Ahmed
Utpal Mohan
Subhendu Bhowmik

Frontiers in Chemistry

doi 10.3389/fchem.2024.1420593

1,502 views

Editorial

Published on 25 Jun 2024

Editorial: Five-membered heterocycles: synthesis and applications

in Medicinal and Pharmaceutical Chemistry

Mohammad Abrar Alam

Frontiers in Chemistry

doi 10.3389/fchem.2024.1445671

1,322 views
1 citation