Review

Published on 18 Apr 2024

Fragment-based drug discovery for disorders of the central nervous system: designing better drugs piece by piece

in Medicinal and Pharmaceutical Chemistry

Bill W. G. L. Chan
Nicholas B. Lynch
Wendy Tran
Jack M. Joyce
G. Paul Savage
Wim Meutermans
Andrew P. Montgomery
Michael Kassiou

Frontiers in Chemistry

doi 10.3389/fchem.2024.1379518

2,937 views
1 citation

Editorial

Published on 17 Apr 2024

Editorial: Medicinal chemistry of active pharmaceutical ingredients of drug products

in Medicinal and Pharmaceutical Chemistry

Mohd Imran
Qasim M. Alhadidi
Shah Alam Khan
Hamdy Khamees Thabet
Ozair Alam
Faiyaz Shakeel
Ziyaur Rahman
Muhammad Wahab Amjad

Frontiers in Chemistry

doi 10.3389/fchem.2024.1409042

865 views

Correction

Published on 17 Apr 2024

Corrigendum: Developments in 177Lu-based radiopharmaceutical therapy and dosimetry

in Medicinal and Pharmaceutical Chemistry

Siju C. George
E. James Jebaseelan Samuel

Frontiers in Chemistry

doi 10.3389/fchem.2024.1410803

516 views
1 citation

Editorial

Published on 16 Apr 2024

Editorial: Small molecules and smart drug delivery systems for combination cancer immunotherapy

in Medicinal and Pharmaceutical Chemistry

Claudia Ferroni
Greta Varchi

Frontiers in Chemistry

doi 10.3389/fchem.2024.1412624

690 views

Original Research

Published on 16 Apr 2024

Discovery of novel melatonin–mydroxyquinoline hybrids as multitarget strategies for Alzheimer’s disease therapy

in Medicinal and Pharmaceutical Chemistry

Wei Wang
Tingting Pan
Rui Su
Mingbin Chen
Wandi Xiong
Congjun Xu
Ling Huang

Frontiers in Chemistry

doi 10.3389/fchem.2024.1374930

1,119 views
1 citation

Original Research

Published on 16 Apr 2024

Integration of the Butina algorithm and ensemble learning strategies for the advancement of a pharmacophore ligand-based model: an in silico investigation of apelin agonists

in Medicinal and Pharmaceutical Chemistry

Xuan-Truc Dinh Tran
Tieu-Long Phan
Van-Thinh To
Ngoc-Vi Nguyen Tran
Nhu-Ngoc Song Nguyen
Dong-Nghi Hoang Nguyen
Ngoc-Tam Nguyen Tran
Tuyen Ngoc Truong

Frontiers in Chemistry

doi 10.3389/fchem.2024.1382319

1,280 views
1 citation

Review

Published on 11 Apr 2024

Biological activity of the essential oil of Drimys winteri

in Medicinal and Pharmaceutical Chemistry

Myriam Navarro
Felipe Urrejola
Misael Espinoza
Simón Silva
Sebastián González
Diego Utreras
Katia Fernandez
Jessica Bravo

Frontiers in Chemistry

doi 10.3389/fchem.2024.1321300

1,637 views

Original Research

Published on 08 Apr 2024

Exploring the multifaceted bioactivities of Lavandula pinnata L. essential oil: promising pharmacological activities

in Medicinal and Pharmaceutical Chemistry

Mounir Haddou
Amine Elbouzidi
Mohamed Taibi
Abdellah Baraich
El Hassania Loukili
Reda Bellaouchi
Ennouaamane Saalaoui
Abdeslam Asehraou
Ahmad Mohammad Salamatullah
Mohammed Bourhia

Frontiers in Chemistry

doi 10.3389/fchem.2024.1383731

1,616 views
3 citations

Original Research

Published on 05 Apr 2024

Exploring theophylline-1,2,4-triazole tethered N-phenylacetamide derivatives as antimicrobial agents: unraveling mechanisms via structure-activity relationship, in vitro validation, and in silico insights

in Medicinal and Pharmaceutical Chemistry

Sadaf Saeed
Irum Shahzadi
Ameer Fawad Zahoor
Aamal A. Al-Mutairi
Shagufta Kamal
Shah Faisal
Ali Irfan
Sami A. Al-Hussain
Muhammed Tilahun Muhammed
Magdi E. A. Zaki

Frontiers in Chemistry

doi 10.3389/fchem.2024.1372378

1,401 views
1 citation

Original Research

Published on 02 Apr 2024

Efficacy and classification of Sesamum indicum linn seeds with Rosa damascena mill oil in uncomplicated pelvic inflammatory disease using machine learning

in Medicinal and Pharmaceutical Chemistry

Sumbul
Arshiya Sultana
Md Belal Bin Heyat
Khaleequr Rahman
Faijan Akhtar
Saba Parveen
Mercedes Briones Urbano
Vivian Lipari
Isabel De la Torre Díez
Azmat Ali Khan

Frontiers in Chemistry

doi 10.3389/fchem.2024.1361980

2,525 views
5 citations

Original Research

Published on 27 Mar 2024

HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy–an in vitro exploration

in Medicinal and Pharmaceutical Chemistry

Matilde Tubertini
Luca Menilli
Celeste Milani
Cecilia Martini
Maria Luisa Navacchia
Marta Nugnes
Manuela Bartolini
Marina Naldi
Daniele Tedesco
Elisa Martella

Frontiers in Chemistry

doi 10.3389/fchem.2024.1378233

2,204 views

Original Research

Published on 25 Mar 2024

Comparative study of the chemical composition, antioxidant, and antimicrobial activity of the essential oils extracted from Lavandula abrialis and Lavandula stoechas: in vitro and in silico analysis

in Medicinal and Pharmaceutical Chemistry

Mohamed Radi
Zaina Eddardar
Aziz Drioiche
Firdaous Remok
Md. Eram Hosen
Khalid Zibouh
Brahim Ed-Damsyry
Amale Bouatkiout
Sanae Amine
Hanane Touijer

Frontiers in Chemistry

doi 10.3389/fchem.2024.1353385

2,282 views

Correction

Published on 22 Mar 2024

Corrigendum: Double cross-linked graphene oxide hydrogel for promoting healing of diabetic ulcers

in Medicinal and Pharmaceutical Chemistry

Wenxu Liu
Yunfang Yang
Meiying Li
Jingxin Mo

Frontiers in Chemistry

doi 10.3389/fchem.2024.1393387

1,236 views

Original Research

Published on 21 Mar 2024

Revisiting methotrexate and phototrexate Zinc15 library-based derivatives using deep learning in-silico drug design approach

in Medicinal and Pharmaceutical Chemistry

Farhan Siddique
Ahmar Anwaar
Maryam Bashir
Sumaira Nadeem
Ravi Rawat
Volkan Eyupoglu
Samina Afzal
Mehvish Bibi
Yousef A. Bin Jardan
Mohammed Bourhia

Frontiers in Chemistry

doi 10.3389/fchem.2024.1380266

2,690 views
2 citations

Original Research

Published on 18 Mar 2024

Synthesis and biological evaluation of novel benzothiazole derivatives as potential anticancer and antiinflammatory agents

in Medicinal and Pharmaceutical Chemistry

Xuemei Xu
Zhaojingtao Zhu
Siyu Chen
Yanneng Fu
Jinxia Zhang
Yangyang Guo
Zhouyang Xu
Yingying Xi
Xuebao Wang
Faqing Ye

Frontiers in Chemistry

doi 10.3389/fchem.2024.1384301

4,091 views
4 citations

Original Research

Published on 13 Mar 2024

Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors

in Medicinal and Pharmaceutical Chemistry

Muhammad Akash
Sumera Zaib
Matloob Ahmad
Sadia Sultan
Sami A. Al-Hussain

Frontiers in Chemistry

doi 10.3389/fchem.2024.1371377

1,410 views
2 citations

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Articles

Fragment-based drug discovery for disorders of the central nervous system: designing better drugs piece by piece

Editorial: Medicinal chemistry of active pharmaceutical ingredients of drug products

Corrigendum: Developments in 177Lu-based radiopharmaceutical therapy and dosimetry

Editorial: Small molecules and smart drug delivery systems for combination cancer immunotherapy

Discovery of novel melatonin–mydroxyquinoline hybrids as multitarget strategies for Alzheimer’s disease therapy

Integration of the Butina algorithm and ensemble learning strategies for the advancement of a pharmacophore ligand-based model: an in silico investigation of apelin agonists

Biological activity of the essential oil of Drimys winteri

Exploring the multifaceted bioactivities of Lavandula pinnata L. essential oil: promising pharmacological activities

Exploring theophylline-1,2,4-triazole tethered N-phenylacetamide derivatives as antimicrobial agents: unraveling mechanisms via structure-activity relationship, in vitro validation, and in silico insights

Efficacy and classification of Sesamum indicum linn seeds with Rosa damascena mill oil in uncomplicated pelvic inflammatory disease using machine learning

HSA-nanobinders crafted from bioresponsive prodrugs for combined cancer chemoimmunotherapy–an in vitro exploration

Comparative study of the chemical composition, antioxidant, and antimicrobial activity of the essential oils extracted from Lavandula abrialis and Lavandula stoechas: in vitro and in silico analysis

Corrigendum: Double cross-linked graphene oxide hydrogel for promoting healing of diabetic ulcers

Revisiting methotrexate and phototrexate Zinc15 library-based derivatives using deep learning in-silico drug design approach

Synthesis and biological evaluation of novel benzothiazole derivatives as potential anticancer and antiinflammatory agents

Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors