Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 31 Oct 2024

Aspidosperma nitidum reduces parasite load and modulates cytokines in BALB/c mice infected with Leishmania (Leishmania) amazonensis

in Medicinal and Pharmaceutical Chemistry

Heliton Patrick Cordovil Brígido
Everton Luiz Pompeu Varela
Antônio Rafael Quadros Gomes
Jorddy Neves Cruz
Juliana Correa-Barbosa
José Edson de Sousa Siqueira
Cristian Kallahan Silva Chagas
Andrey Moacir do Rosário Marinho
Liliane Almeida Carneiro
Márlia Regina Coelho-Ferreira

Frontiers in Chemistry

doi 10.3389/fchem.2024.1492770

799 views
3 citations

Original Research

Published on 30 Oct 2024

Exploring the mechanism of tetramethylpyrazine in the treatment of osteoarthritis based on network pharmacology

in Medicinal and Pharmaceutical Chemistry

Juncen Li
Daiying Song
Bohui Li
Yajie Wang
Huilin Sun
Qinglin Li
Xiangming Lin
Di Wang
Guangdong Zhou
Yu Liu

Frontiers in Chemistry

doi 10.3389/fchem.2024.1415390

1,745 views
1 citation

Original Research

Published on 24 Oct 2024

Antioxidant, Anti-Alzheimer’s, anticancer, and cytotoxic properties of peanut oil: in vitro, in silico, and GC-MS analysis

in Medicinal and Pharmaceutical Chemistry

Hanène Djeghim
Djamila Benouchenne
El Hassen Mokrani
Huda Alsaeedi
David Cornu
Mikhael Bechelany
Ahmed Barhoum

Frontiers in Chemistry

doi 10.3389/fchem.2024.1487084

5,510 views
1 citation

Original Research

Published on 23 Oct 2024

Synthesis of new triazole derivatives and their potential applications for removal of heavy metals from aqueous solution and antibacterial activities

in Medicinal and Pharmaceutical Chemistry

Chunyun Xu
Na Yang
Haichun Yu
Xiaojing Wang

Frontiers in Chemistry

doi 10.3389/fchem.2024.1473097

1,149 views
1 citation

Original Research

Published on 21 Oct 2024

Development of novel CDK9 and CYP3A4 inhibitors for cancer therapy through field and computational approaches

in Medicinal and Pharmaceutical Chemistry

Aisha A. Alsfouk
Abdelmoujoud Faris
Ivana Cacciatore
Radwan Alnajjar

Frontiers in Chemistry

doi 10.3389/fchem.2024.1473398

1,407 views
1 citation

Original Research

Published on 16 Oct 2024

Synthesis and antibacterial potential of novel thymol derivatives against methicillin-resistant Staphylococcus aureus and P. aeruginosa pathogenic bacteria

in Medicinal and Pharmaceutical Chemistry

Ashutosh Shahi
Rakshit Manhas
Srija Bhattacharya
Arti Rathore
Puneet Kumar
Jayanta Samanta
Manish Kumar Sharma
Avisek Mahapa
Prasoon Gupta
Jasha Momo H. Anal

Frontiers in Chemistry

doi 10.3389/fchem.2024.1482852

1,642 views
3 citations

Original Research

Published on 15 Oct 2024

Sustainable synthesis of silver nanoparticles from Azadirachta indica: antimicrobial, antioxidant and in silico analysis for periodontal treatment

in Medicinal and Pharmaceutical Chemistry

Binapani Barik
Bhabani Sankar Satapathy
Gurudutta Pattnaik
Desai Vijay Bhavrao
Krishna Prasad Shetty

Frontiers in Chemistry

doi 10.3389/fchem.2024.1489253

1,403 views
1 citation

Original Research

Published on 08 Oct 2024

Computational exploration of acefylline derivatives as MAO-B inhibitors for Parkinson’s disease: insights from molecular docking, DFT, ADMET, and molecular dynamics approaches

in Medicinal and Pharmaceutical Chemistry

Ali Irfan
Ameer Fawad Zahoor
Yassir Boulaamane
Sadia Javed
Huma Hameed
Amal Maurady
Muhammed Tilahun Muhammed
Sajjad Ahmad
Aamal A. Al-Mutairi
Irum Shahzadi

Frontiers in Chemistry

doi 10.3389/fchem.2024.1449165

1,748 views
1 citation

Original Research

Published on 08 Oct 2024

Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP

in Medicinal and Pharmaceutical Chemistry

William J. Netzer
Anjana Sinha
Mondana Ghias
Emily Chang
Katherina Gindinova
Emily Mui
Ji-Seon Seo
Subhash C. Sinha

Frontiers in Chemistry

doi 10.3389/fchem.2024.1381205

786 views

Original Research

Published on 03 Oct 2024

Stemona alkaloid derivative induce ferroptosis of colorectal cancer cell by mediating carnitine palmitoyltransferase 1

in Medicinal and Pharmaceutical Chemistry

He Yang
Ling Wang
Mengcheng Zhang
Xingkang Wu
Zhenyu Li
Kaiqing Ma

Frontiers in Chemistry

doi 10.3389/fchem.2024.1478674

1,225 views
1 citation

Review

Published on 26 Sep 2024

Venom-derived peptides for breaking through the glass ceiling of drug development

in Medicinal and Pharmaceutical Chemistry

Lou Freuville
Chloé Matthys
Loïc Quinton
Jean-Pierre Gillet

Frontiers in Chemistry

doi 10.3389/fchem.2024.1465459

3,558 views

Original Research

Published on 24 Sep 2024

Topological indices based VIKOR assisted multi-criteria decision technique for lung disorders

in Medicinal and Pharmaceutical Chemistry

Tahreem Ashraf
Nazeran Idrees

Frontiers in Chemistry

doi 10.3389/fchem.2024.1407911

981 views
1 citation

Original Research

Published on 20 Sep 2024

Structure-based virtual screening towards the discovery of novel thrombin inhibitors with Anti-HCC activities

in Medicinal and Pharmaceutical Chemistry

Xiaoxi Zhang
Xumei Zheng
Chun Han
Lintao Wu

Frontiers in Chemistry

doi 10.3389/fchem.2024.1451574

809 views
1 citation

Editorial

Published on 19 Sep 2024

Editorial: Advances in wound repair and regeneration: novel materials, targets and applications

in Medicinal and Pharmaceutical Chemistry

Xinwei Cheng
Jia Zhou

Frontiers in Chemistry

doi 10.3389/fchem.2024.1487091

565 views

Editorial

Published on 17 Sep 2024

Editorial: Novel compounds from chemistry to druggable candidates

in Medicinal and Pharmaceutical Chemistry

Pete Rose
Jawad Nasim
Yi-Zhun Zhu

Frontiers in Chemistry

doi 10.3389/fchem.2024.1494407

692 views

Original Research

Published on 13 Sep 2024

Phytochemical analysis, identification of bioactive compounds using GC-MS, in vitro and in silico hypoglycemic potential, in vitro antioxidant potential, and in silico ADME analysis of Chlorophytum comosum root and leaf

in Medicinal and Pharmaceutical Chemistry

P. Kavya
R. C. Theijeswini
M. Gayathri

Frontiers in Chemistry

doi 10.3389/fchem.2024.1458505

2,039 views