Original Research

Published on 04 May 2021

Synthesis, Antitumor and Antiviral In Vitro Activities of New Benzotriazole-Dicarboxamide Derivatives

in Medicinal and Pharmaceutical Chemistry

Roberta Ibba
Sandra Piras
Paola Corona
Federico Riu
Roberta Loddo
Ilenia Delogu
Gabriella Collu
Giuseppina Sanna
Paola Caria
Tinuccia Dettori

Frontiers in Chemistry

doi 10.3389/fchem.2021.660424

3,871 views
13 citations

Review

Published on 04 May 2021

Rational Design of Peptide-Based Inhibitors Disrupting Protein-Protein Interactions

in Medicinal and Pharmaceutical Chemistry

Xuefei Wang
Duan Ni
Yaqin Liu
Shaoyong Lu

Frontiers in Chemistry

doi 10.3389/fchem.2021.682675

22,058 views
91 citations

Perspective

Published on 04 May 2021

Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules

in Medicinal and Pharmaceutical Chemistry

Alastair D. G. Lawson
Malcolm MacCoss
Dominique L. Baeten
Alex Macpherson
Jiye Shi
Alistair J. Henry

Frontiers in Chemistry

doi 10.3389/fchem.2021.668186

2,771 views
4 citations

Editorial

Published on 30 Apr 2021

Editorial: Phosphonate Chemistry in Drug Design and Development

in Medicinal and Pharmaceutical Chemistry

Petri A. Turhanen
Konstantinos D. Demadis
Pawel Kafarski

Frontiers in Chemistry

doi 10.3389/fchem.2021.695128

3,322 views
14 citations

Original Research

Published on 30 Apr 2021

Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes

in Medicinal and Pharmaceutical Chemistry

Maarten Sijm
Louis Maes
Iwan J. P. de Esch
Guy Caljon
Geert Jan Sterk
Rob Leurs

Frontiers in Chemistry

doi 10.3389/fchem.2021.608438

3,151 views
2 citations

Original Research

Published on 30 Apr 2021

Synthesis, Biological Evaluation, and QSAR Studies of 3-Iodochromone Derivatives as Potential Fungicides

in Medicinal and Pharmaceutical Chemistry

Parshant Kaushik
Najam A. Shakil
Virendra S. Rana

Frontiers in Chemistry

doi 10.3389/fchem.2021.636882

2,545 views
5 citations

Original Research

Published on 29 Apr 2021

Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis

in Medicinal and Pharmaceutical Chemistry

Erik Hembre
Julie V. Early
Joshua Odingo
Catherine Shelton
Olena Anoshchenko
Junitta Guzman
Lindsay Flint
Devon Dennison
Matthew B. McNeil
Aaron Korkegian

Frontiers in Chemistry

doi 10.3389/fchem.2021.613349

2,160 views
2 citations

Review

Published on 29 Apr 2021

Vaccaria segetalis: A Review of Ethnomedicinal, Phytochemical, Pharmacological, and Toxicological Findings

in Medicinal and Pharmaceutical Chemistry

Meng Tian
Yuwen Huang
Xin Wang
Maosheng Cao
Zijiao Zhao
Tong Chen
Chenfeng Yuan
Nan Wang
Boqi Zhang
Chunjin Li

Frontiers in Chemistry

doi 10.3389/fchem.2021.666280

5,520 views
10 citations

Review

Published on 29 Apr 2021

Application of Amino Acids in the Structural Modification of Natural Products: A Review

in Medicinal and Pharmaceutical Chemistry

Qian Xu
Hao Deng
Xiaoting Li
Zhe-Shan Quan

Frontiers in Chemistry

doi 10.3389/fchem.2021.650569

16,499 views
39 citations

Original Research

Published on 27 Apr 2021

Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery

in Medicinal and Pharmaceutical Chemistry

Crhisllane Rafaele dos Santos Vasconcelos
Antonio Mauro Rezende

Frontiers in Chemistry

doi 10.3389/fchem.2021.607139

4,521 views
7 citations

Review

Published on 23 Apr 2021

Reactive Oxygen Species Responsive Polymers for Drug Delivery Systems

in Medicinal and Pharmaceutical Chemistry

Fengxiang Gao
Zhengrong Xiong

Frontiers in Chemistry

doi 10.3389/fchem.2021.649048

10,764 views
57 citations

Original Research

Published on 16 Apr 2021

Biological Evaluation of [18F]AlF-NOTA-NSC-GLU as a Positron Emission Tomography Tracer for Hepatocellular Carcinoma

in Medicinal and Pharmaceutical Chemistry

Liping Lin
Xianhong Xiang
Shu Su
Shaoyu Liu
Ying Xiong
Hui Ma
Gongjun Yuan
Dahong Nie
Ganghua Tang

Frontiers in Chemistry

doi 10.3389/fchem.2021.630452

2,977 views
4 citations

Original Research

Published on 14 Apr 2021

Synthesis Candidates Herbicide Through Optimization Quinclorac Containing 3-Methyl-1H-pyrazol-5-yl

in Medicinal and Pharmaceutical Chemistry

Dingfeng Luo
Haodong Bai
Xiaomao Zhou
Lamei Wu
Chengjia Zhang
Zhongchi Wu
Zuren Li
Lianyang Bai

Frontiers in Chemistry

doi 10.3389/fchem.2021.647472

2,609 views
2 citations

Mini Review

Published on 07 Apr 2021

Advanced Biomedical Applications of Reactive Oxygen Species-Based Nanomaterials in Lung Cancer

in Medicinal and Pharmaceutical Chemistry

Nan Zhao
Hua Xin
Lening Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2021.649772

3,213 views
12 citations

Editorial

Published on 19 Mar 2021

Editorial: Computational Drug Discovery for Targeting of Protein-Protein Interfaces

in Medicinal and Pharmaceutical Chemistry

Massimiliano Meli
Alessandro Pandini
Giulia Morra

Frontiers in Chemistry

doi 10.3389/fchem.2021.670569

1,822 views
2 citations

Editorial

Published on 18 Mar 2021

Editorial: The Golden Future in Medicinal Chemistry: Perspectives and Resources From Old and New Gold-Based Drug Candidates

in Medicinal and Pharmaceutical Chemistry

Lara Massai
Sanja Grguric-Sipka
Wukun Liu
Benoît Bertrand
Alessandro Pratesi

Frontiers in Chemistry

doi 10.3389/fchem.2021.665244

2,046 views
5 citations

Navigation group

Articles

Synthesis, Antitumor and Antiviral In Vitro Activities of New Benzotriazole-Dicarboxamide Derivatives

Rational Design of Peptide-Based Inhibitors Disrupting Protein-Protein Interactions

Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules

Editorial: Phosphonate Chemistry in Drug Design and Development

Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes

Synthesis, Biological Evaluation, and QSAR Studies of 3-Iodochromone Derivatives as Potential Fungicides

Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis

Vaccaria segetalis: A Review of Ethnomedicinal, Phytochemical, Pharmacological, and Toxicological Findings

Application of Amino Acids in the Structural Modification of Natural Products: A Review

Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery

Reactive Oxygen Species Responsive Polymers for Drug Delivery Systems

Biological Evaluation of [18F]AlF-NOTA-NSC-GLU as a Positron Emission Tomography Tracer for Hepatocellular Carcinoma

Synthesis Candidates Herbicide Through Optimization Quinclorac Containing 3-Methyl-1H-pyrazol-5-yl

Advanced Biomedical Applications of Reactive Oxygen Species-Based Nanomaterials in Lung Cancer

Editorial: Computational Drug Discovery for Targeting of Protein-Protein Interfaces

Editorial: The Golden Future in Medicinal Chemistry: Perspectives and Resources From Old and New Gold-Based Drug Candidates