Original Research

Published on 17 Sep 2021

Benzopyrazine-Based Small Molecule Inhibitors As Trypanocidal and Leishmanicidal Agents: Green Synthesis, In Vitro, and In Silico Evaluations

in Medicinal and Pharmaceutical Chemistry

Jonathan Rock
Daniel Garcia
Omar Espino
Shaila A. Shetu
Manuel J. Chan-Bacab
Rosa Moo-Puc
Navin B. Patel
Gildardo Rivera
Debasish Bandyopadhyay

Frontiers in Chemistry

doi 10.3389/fchem.2021.725892

3,738 views
6 citations

Original Research

Published on 15 Sep 2021

Uncommon Bis-Amide Matrine-type Alkaloids From Sophora alopecuroides With Anti-inflammatory Effects

in Medicinal and Pharmaceutical Chemistry

Ding Luo
Zhenchao Tu
Wenjing Yin
Chunlin Fan
Nenghua Chen
Zhongnan Wu
Weilong Ding
Yaolan Li
Guocai Wang
Yubo Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2021.740421

2,739 views
4 citations

Mini Review

Published on 10 Sep 2021

Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19

in Medicinal and Pharmaceutical Chemistry

Adalberto Fernandes Santos
Pedro Póvoa
Paulo Paixão
António Mendonça
Luís Taborda-Barata

Frontiers in Chemistry

doi 10.3389/fchem.2021.685196

11,150 views
50 citations

Original Research

Published on 24 Aug 2021

How Different Albumin-Binders Drive Probe Distribution of Fluorescent RGD Mimetics

in Medicinal and Pharmaceutical Chemistry

Carsten Höltke
Wael Alsibai
Martin Grewer
Miriam Stölting
Christiane Geyer
Michel Eisenblätter
Moritz Wildgruber
Anne Helfen

Frontiers in Chemistry

doi 10.3389/fchem.2021.689850

3,179 views
5 citations

Original Research

Published on 17 Aug 2021

Aspulvinones Suppress Postprandial Hyperglycemia as Potent α-Glucosidase Inhibitors From Aspergillus terreus ASM-1

in Medicinal and Pharmaceutical Chemistry

Changjing Wu
Xiang Cui
Luzhen Sun
Jiajia Lu
Feng Li
Minghui Song
Yunxia Zhang
Xinqi Hao
Congkui Tian
Maoping Song

Frontiers in Chemistry

doi 10.3389/fchem.2021.736070

2,983 views
11 citations

Original Research

Published on 12 Aug 2021

Isolation and Identification of Isocoumarin Derivatives With Specific Inhibitory Activity Against Wnt Pathway and Metabolome Characterization of Lasiodiplodia venezuelensis

in Medicinal and Pharmaceutical Chemistry

Léonie Pellissier
Alexey Koval
Laurence Marcourt
Emerson Ferreira Queiroz
Nicole Lecoultre
Sara Leoni
Luis-Manuel Quiros-Guerrero
Morgane Barthélémy
Bastiaan L. Duivelshof
Davy Guillarme

Frontiers in Chemistry

doi 10.3389/fchem.2021.664489

3,959 views
9 citations

Original Research

Published on 11 Aug 2021

The Use of Bionic Prodrugs for the Enhancement of Low Dose Radiotherapy

in Medicinal and Pharmaceutical Chemistry

Yanhong Duo

Frontiers in Chemistry

doi 10.3389/fchem.2021.710250

2,587 views
1 citation

Review

Published on 11 Aug 2021

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

in Medicinal and Pharmaceutical Chemistry

Praveen Kumar Jadi
Prerana Sharma
Bharathi Bhogapurapu
Sanhita Roy

Frontiers in Chemistry

doi 10.3389/fchem.2021.694998

13,174 views
13 citations

Review

Published on 09 Aug 2021

Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism

in Medicinal and Pharmaceutical Chemistry

Leiya Kou
Shuang Wei
Pei Kou

Frontiers in Chemistry

doi 10.3389/fchem.2021.733463

3,052 views
12 citations

Review

Published on 02 Aug 2021

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

in Medicinal and Pharmaceutical Chemistry

Gurcan Gunaydin
M. Emre Gedik
Seylan Ayan

Frontiers in Chemistry

doi 10.3389/fchem.2021.686303

36,967 views
250 citations

Editorial

Published on 30 Jul 2021

Editorial: Application of PROTACs as a Novel Strategy for Drug Discovery

in Medicinal and Pharmaceutical Chemistry

Hany S. Ibrahim
Wolfgang Sippl

Frontiers in Chemistry

doi 10.3389/fchem.2021.740196

2,661 views

Review

Published on 23 Jul 2021

Cellular Basis of Organotin(IV) Derivatives as Anticancer Metallodrugs: A Review

in Medicinal and Pharmaceutical Chemistry

Sharifah Nadhira Syed Annuar
Nurul Farahana Kamaludin
Normah Awang
Kok Meng Chan

Frontiers in Chemistry

doi 10.3389/fchem.2021.657599

5,936 views
63 citations

Original Research

Published on 22 Jul 2021

Synthetic Integrin-Targeting Dextran-Fc Hybrids Efficiently Inhibit Tumor Proliferation In Vitro

in Medicinal and Pharmaceutical Chemistry

Hendrik Schneider
Simon Englert
Arturo Macarrón Palacios
Jorge Alberto Lerma Romero
Ataurehman Ali
Olga Avrutina
Harald Kolmar

Frontiers in Chemistry

doi 10.3389/fchem.2021.693097

2,682 views
3 citations

Original Research

Published on 12 Jul 2021

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety

in Medicinal and Pharmaceutical Chemistry

Wenneng Wu
Wenjun Lan
Chenyan Wu
Qiang Fei

Frontiers in Chemistry

doi 10.3389/fchem.2021.695628

5,766 views
32 citations

Perspective

Published on 05 Jul 2021

Reversible Covalent PROTACs: Novel and Efficient Targeted Degradation Strategy

in Medicinal and Pharmaceutical Chemistry

Minghua Yuan
Yanan Chu
Yongtao Duan

Frontiers in Chemistry

doi 10.3389/fchem.2021.691093

7,000 views
11 citations

Original Research

Published on 28 Jun 2021

In Vivo Behavior of the Antibacterial Peptide Cyclo[RRRWFW], Explored Using a 3-Hydroxychromone-Derived Fluorescent Amino Acid

in Medicinal and Pharmaceutical Chemistry

Sergii Afonin
Serhii Koniev
Laetitia Préau
Masanari Takamiya
Alexander V. Strizhak
Oleg Babii
Andrii Hrebonkin
Vasyl G. Pivovarenko
Margitta Dathe
Ferdinand le Noble

Frontiers in Chemistry

doi 10.3389/fchem.2021.688446

3,267 views
5 citations

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Articles

Benzopyrazine-Based Small Molecule Inhibitors As Trypanocidal and Leishmanicidal Agents: Green Synthesis, In Vitro, and In Silico Evaluations

Uncommon Bis-Amide Matrine-type Alkaloids From Sophora alopecuroides With Anti-inflammatory Effects

Changes in Glycolytic Pathway in SARS-COV 2 Infection and Their Importance in Understanding the Severity of COVID-19

How Different Albumin-Binders Drive Probe Distribution of Fluorescent RGD Mimetics

Aspulvinones Suppress Postprandial Hyperglycemia as Potent α-Glucosidase Inhibitors From Aspergillus terreus ASM-1

Isolation and Identification of Isocoumarin Derivatives With Specific Inhibitory Activity Against Wnt Pathway and Metabolome Characterization of Lasiodiplodia venezuelensis

The Use of Bionic Prodrugs for the Enhancement of Low Dose Radiotherapy

Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis

Current Progress and Perspectives on Using Gold Compounds for the Modulation of Tumor Cell Metabolism

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

Editorial: Application of PROTACs as a Novel Strategy for Drug Discovery

Cellular Basis of Organotin(IV) Derivatives as Anticancer Metallodrugs: A Review

Synthetic Integrin-Targeting Dextran-Fc Hybrids Efficiently Inhibit Tumor Proliferation In Vitro

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety

Reversible Covalent PROTACs: Novel and Efficient Targeted Degradation Strategy

In Vivo Behavior of the Antibacterial Peptide Cyclo[RRRWFW], Explored Using a 3-Hydroxychromone-Derived Fluorescent Amino Acid