Mini Review

Published on 04 Nov 2021

Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus

in Medicinal and Pharmaceutical Chemistry

Sun Liu Rei Yan
Felipe Wakasuqui
Xiaochen Du
Matthew R. Groves
Carsten Wrenger

Frontiers in Chemistry

doi 10.3389/fchem.2021.742175

3,597 views
3 citations

Review

Published on 03 Nov 2021

Quinazoline Derivatives as Potential Therapeutic Agents in Urinary Bladder Cancer Therapy

in Medicinal and Pharmaceutical Chemistry

Paulina Wdowiak
Joanna Matysiak
Piotr Kuszta
Katarzyna Czarnek
Ewa Niezabitowska
Tomasz Baj

Frontiers in Chemistry

doi 10.3389/fchem.2021.765552

8,814 views
30 citations

Original Research

Published on 02 Nov 2021

Effective Search of Triterpenes with Anti-HSV-1 Activity Using a Classification Model by Logistic Regression

in Medicinal and Pharmaceutical Chemistry

Keiko Ogawa
Seikou Nakamura
Haruka Oguri
Kaori Ryu
Taichi Yoneda
Rumiko Hosoki

Frontiers in Chemistry

doi 10.3389/fchem.2021.763794

2,860 views
4 citations

Original Research

Published on 29 Oct 2021

Semi-Synthesis of Marine-Derived Ilamycin F Derivatives and Their Antitubercular Activities

in Medicinal and Pharmaceutical Chemistry

Jun Li
Zhiyong Liu
Mingye Hong
Changli Sun
Tianyu Zhang
Hua Zhang
Jianhua Ju
Junying Ma

Frontiers in Chemistry

doi 10.3389/fchem.2021.774555

3,147 views
8 citations

Mini Review

Published on 28 Oct 2021

Chagas Disease Drug Discovery in Latin America—A Mini Review of Antiparasitic Agents Explored Between 2010 and 2021

in Medicinal and Pharmaceutical Chemistry

Ramon G. de Oliveira
Luiza R. Cruz
María C. Mollo
Luiz C. Dias
Jadel M. Kratz

Frontiers in Chemistry

doi 10.3389/fchem.2021.771143

5,389 views
17 citations

Original Research

Published on 25 Oct 2021

Synthesis, 3D-QSAR and Molecular Docking Study of Nopol-Based 1,2,4-Triazole-Thioether Compounds as Potential Antifungal Agents

in Medicinal and Pharmaceutical Chemistry

Xiu Wang
Wengui Duan
Guishan Lin
Baoyu Li
Ming Chen
Fuhou Lei

Frontiers in Chemistry

doi 10.3389/fchem.2021.757584

2,540 views
13 citations

Original Research

Published on 19 Oct 2021

Novel Hydroxytyrosol-Donepezil Hybrids as Potential Antioxidant and Neuroprotective Agents

in Medicinal and Pharmaceutical Chemistry

Paola Costanzo
Manuela Oliverio
Jessica Maiuolo
Sonia Bonacci
Giuseppina De Luca
Mariorosario Masullo
Rosaria Arcone
Antonio Procopio

Frontiers in Chemistry

doi 10.3389/fchem.2021.741444

3,438 views
18 citations

Original Research

Published on 12 Oct 2021

Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors

in Medicinal and Pharmaceutical Chemistry

Mehdi Mahmudpour
Iraj Nabipour
Mohsen Keshavarz
Maryam Farrokhnia

Frontiers in Chemistry

doi 10.3389/fchem.2021.722633

4,255 views
8 citations

Editorial

Published on 07 Oct 2021

Editorial: Discovery and Development of Drugs for Neglected Diseases: Chagas Disease, Human African Trypanosomiasis, and Leishmaniasis

in Medicinal and Pharmaceutical Chemistry

Gildardo Rivera
Navin B. Patel
Debasish Bandyopadhyay

Frontiers in Chemistry

doi 10.3389/fchem.2021.775327

2,935 views

Mini Review

Published on 07 Oct 2021

Mapping, Structure and Modulation of PPI

in Medicinal and Pharmaceutical Chemistry

Elisa Martino
Sara Chiarugi
Francesco Margheriti
Gianpiero Garau

Frontiers in Chemistry

doi 10.3389/fchem.2021.718405

8,997 views
33 citations

Original Research

Published on 07 Oct 2021

Synthesis, Computational Pharmacokinetics Report, Conceptual DFT-Based Calculations and Anti-Acetylcholinesterase Activity of Hydroxyapatite Nanoparticles Derived From Acorus Calamus Plant Extract

in Medicinal and Pharmaceutical Chemistry

Sushma Pradeep
Anisha S. Jain
Chandan Dharmashekara
Shashanka K. Prasad
Nagaraju Akshatha
R. Pruthvish
Raghavendra G Amachawadi
Chandrashekar Srinivasa
Asad Syed
Abdallah M. Elgorban

Frontiers in Chemistry

doi 10.3389/fchem.2021.741037

4,748 views
15 citations

Review

Published on 07 Oct 2021

Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

in Medicinal and Pharmaceutical Chemistry

Keith M. Olson
John R. Traynor
Andrew Alt

Frontiers in Chemistry

doi 10.3389/fchem.2021.671483

8,700 views
11 citations

Review

Published on 30 Sep 2021

Currently Available Strategies for Target Identification of Bioactive Natural Products

in Medicinal and Pharmaceutical Chemistry

Gen Li
Xuling Peng
Yajing Guo
Shaoxuan Gong
Shijie Cao
Feng Qiu

Frontiers in Chemistry

doi 10.3389/fchem.2021.761609

15,497 views
22 citations

Original Research

Published on 22 Sep 2021

Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies

in Medicinal and Pharmaceutical Chemistry

Chao Ma
Mohammed S. Taghour
Amany Belal
Ahmed B. M. Mehany
Naglaa Mostafa
Ahmed Nabeeh
Ibrahim H. Eissa
Ahmed A. Al-Karmalawy

Frontiers in Chemistry

doi 10.3389/fchem.2021.725135

6,880 views
56 citations

Original Research

Published on 20 Sep 2021

Crassifolins Q−W: Clerodane Diterpenoids From Croton crassifolius With Anti-Inflammatory and Anti-Angiogenesis Activities

in Medicinal and Pharmaceutical Chemistry

Canjie Li
Xin Sun
Wenjing Yin
Zhaochun Zhan
Qing Tang
Wenzhi Wang
Xuefang Zhuo
Zhongnan Wu
Haipeng Zhang
Yaolan Li

Frontiers in Chemistry

doi 10.3389/fchem.2021.733350

3,150 views
11 citations

Original Research

Published on 20 Sep 2021

Permeability Data of Organosulfur Garlic Compounds Estimated by Immobilized Artificial Membrane Chromatography: Correlation Across Several Biological Barriers

in Medicinal and Pharmaceutical Chemistry

Daniela Andrea Ramirez
María Fernanda Federici
Jorgelina Cecilia Altamirano
Alejandra Beatriz Camargo
Juan María Luco

Frontiers in Chemistry

doi 10.3389/fchem.2021.690707

3,017 views
9 citations

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Articles

Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against Plasmodium falciparum and Staphylococcus aureus

Quinazoline Derivatives as Potential Therapeutic Agents in Urinary Bladder Cancer Therapy

Effective Search of Triterpenes with Anti-HSV-1 Activity Using a Classification Model by Logistic Regression

Semi-Synthesis of Marine-Derived Ilamycin F Derivatives and Their Antitubercular Activities

Chagas Disease Drug Discovery in Latin America—A Mini Review of Antiparasitic Agents Explored Between 2010 and 2021

Synthesis, 3D-QSAR and Molecular Docking Study of Nopol-Based 1,2,4-Triazole-Thioether Compounds as Potential Antifungal Agents

Novel Hydroxytyrosol-Donepezil Hybrids as Potential Antioxidant and Neuroprotective Agents

Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors

Editorial: Discovery and Development of Drugs for Neglected Diseases: Chagas Disease, Human African Trypanosomiasis, and Leishmaniasis

Mapping, Structure and Modulation of PPI

Synthesis, Computational Pharmacokinetics Report, Conceptual DFT-Based Calculations and Anti-Acetylcholinesterase Activity of Hydroxyapatite Nanoparticles Derived From Acorus Calamus Plant Extract

Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

Currently Available Strategies for Target Identification of Bioactive Natural Products

Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies

Crassifolins Q−W: Clerodane Diterpenoids From Croton crassifolius With Anti-Inflammatory and Anti-Angiogenesis Activities

Permeability Data of Organosulfur Garlic Compounds Estimated by Immobilized Artificial Membrane Chromatography: Correlation Across Several Biological Barriers