Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 07 Mar 2025

Elicitor-driven enhancement of phenolic compounds in geranium callus cultures: phytochemical profiling via LC-MS/MS and biological activities

in Medicinal and Pharmaceutical Chemistry

Amine Elbouzidi
Mohamed Taibi
Abdellah Baraich
Mounir Haddou
Ramzi A. Mothana
Sami A. Alsufyani
Hany W. Darwish
Roland Molinié
Jean-Xavier Fontaine
Ophélie Fliniaux

Frontiers in Chemistry

doi 10.3389/fchem.2025.1537877

610 views

Editorial

Published on 04 Mar 2025

Editorial: Beyond borders: exploring diverse roles of heterocyclic compounds in combatting infections and cancer

in Medicinal and Pharmaceutical Chemistry

Afzal B. Shaik
Richie R. Bhandare
M. Mukhlesur Rahman
Kamal Dua

Frontiers in Chemistry

doi 10.3389/fchem.2025.1578852

543 views

Original Research

Published on 27 Feb 2025

Designing novel cabozantinib analogues as p-glycoprotein inhibitors to target cancer cell resistance using molecular docking study, ADMET screening, bioisosteric approach, and molecular dynamics simulations

in Medicinal and Pharmaceutical Chemistry

Gajendra Singh Thakur
Ajay Kumar Gupta
Dipti Pal
Yogesh Vaishnav
Neeraj Kumar
Sivakumar Annadurai
Sanmati Kumar Jain

Frontiers in Chemistry

doi 10.3389/fchem.2025.1543075

781 views

Original Research

Published on 27 Feb 2025

Mechanism of salidroside promoting testosterone secretion induced by H2O2 in TM3 Leydig cells based on metabolomics and network pharmacology

in Medicinal and Pharmaceutical Chemistry

Zixu Wang
Yunlong Xu
Huazhong Xiong

Frontiers in Chemistry

doi 10.3389/fchem.2025.1544876

590 views

Original Research

Published on 27 Feb 2025

Insight into loading, release, and anticancer activities of the methanol hybridized glauconite nano-sheets as a potential carrier of cisplatin: equilibrium and release kinetics

in Medicinal and Pharmaceutical Chemistry

Haifa E. Alfassam
Nourhan Nasser
Sarah I. Othman
Hanan M. Alharbi
Noof A. Alenazi
Hassan A. Rudyani
Ahmed A. Allam
Wail Al Zoubi
Mostafa R. Abukhadra

Frontiers in Chemistry

doi 10.3389/fchem.2025.1523664

416 views

Original Research

Published on 26 Feb 2025

Discovery of triazole derivatives for biofilm disruption, anti-inflammation and metal ion chelation

in Medicinal and Pharmaceutical Chemistry

Shuang Hong
Hongzhi Lu
Dawei Tian
Yue Chang
Qi Lu
Feng Gao

Frontiers in Chemistry

doi 10.3389/fchem.2025.1545259

587 views

Original Research

Published on 25 Feb 2025

Molecular docking, free energy calculations, ADMETox studies, DFT analysis, and dynamic simulations highlighting a chromene glycoside as a potential inhibitor of PknG in Mycobacterium tuberculosis

in Medicinal and Pharmaceutical Chemistry

Muharib Alruwaili
Tilal Elsaman
Magdi Awadalla Mohamed
Abozer Y. Elderdery
Jeremy Mills
Yasir Alruwaili
Siddiqa M. A. Hamza
Salma Elhadi Ibrahim Mekki
Hazim Abdullah Alotaibi
Maily J. Alrowily

Frontiers in Chemistry

doi 10.3389/fchem.2025.1531152

901 views

Original Research

Published on 24 Feb 2025

Novel idebenone derivatives attenuated oxidative stress injury and myocardial damage

in Medicinal and Pharmaceutical Chemistry

Yuwei Peng
Yishan Guo
Xinyi Yang
Yulan Liu
Xun Xu
Junhong Chen
Xueyi Liu
Zhenrou Xie
Zhiqiang Yu
Dudu Wu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1544616

664 views

Correction

Published on 21 Feb 2025

Corrigendum: Antioxidant, Anti-Alzheimer’s, anticancer, and cytotoxic properties of peanut oil: in vitro, in silico, and GC-MS analysis

in Medicinal and Pharmaceutical Chemistry

Hanène Djeghim
Djamila Benouchenne
El Hassen Mokrani
Huda Alsaeedi
David Cornu
Mikhael Bechelany
Ahmed Barhoum

Frontiers in Chemistry

doi 10.3389/fchem.2025.1563210

384 views

Original Research

Published on 19 Feb 2025

Therapeutic potential of Laurus nobilis extract by experimental and computational approaches: phenolic content and bioactivities for antioxidant, antidiabetic, and anticholinergic properties

in Medicinal and Pharmaceutical Chemistry

Sevgi Altın
Mesut Işık
Cemalettin Alp
Emrah Dikici
Ekrem Köksal
Kevser Kübra Kırboğa
Mithun Rudrapal
Gourav Rakshit
Şükrü Beydemir
Johra Khan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1541250

1,241 views

Original Research

Published on 13 Feb 2025

Anti-proliferative effects of a polyherbal formulation on HL-60, HCT-116, and HeLa cell lines: a docking simulation and response surface design-aided study

in Medicinal and Pharmaceutical Chemistry

Chukwuebuka Egbuna
Kingsley C. Patrick-Iwuanyanwu
Eugene N. Onyeike
Johra Khan
Sahar AlDosari
Sadaf Jahan
Kamoru A. Adedokun
Sikiru O. Imodoye
Ibrahim O. Bello
Chukwuemelie Z. Uche

Frontiers in Chemistry

doi 10.3389/fchem.2025.1487887

887 views

Original Research

Accepted on 12 Feb 2025

Antioxidant Activity and Selective Cytotoxicity in HCT-116 and WI-38 cell Lines of LC-MS/MS profiled extract from Capparis spinosa L

in Medicinal and Pharmaceutical Chemistry

Amjad Ibrahim Oraibia
Ashour H. Dawoodd
Ghada Trabelsi
Ousman B.Mahamat
Leila chekir -Ghedira
Soumaya Kilani

Frontiers in Chemistry

doi 10.3389/fchem.2025.1540174

136 views

Original Research

Published on 12 Feb 2025

Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents

in Medicinal and Pharmaceutical Chemistry

Tulika Anthwal
Swati Pant
Preeti Rana
Sumitra Nain

Frontiers in Chemistry

doi 10.3389/fchem.2024.1515866

761 views

Original Research

Published on 04 Feb 2025

Molecular characterization, chemical profile and biological properties of essential oils from Chamaemelum nobile (L.) flowers of Morocco: in vitro and in silico studies

in Medicinal and Pharmaceutical Chemistry

El-Mehdi El-Assri
Youssef El-Assri
Rajae El Brahimi
Mohamed El fadili
Asmae Baghouz
Hatem A. Abuelizz
Sara Er-Rahmani
Amal Lahkimi
Abdelhak Bouia

Frontiers in Chemistry

doi 10.3389/fchem.2025.1539872

834 views

Editorial

Published on 03 Feb 2025

Editorial: Exploring novel approaches to small molecule kinase inhibitors in cancer treatment

in Medicinal and Pharmaceutical Chemistry

Anna Carbone
Rafael M. Couñago
Cristian O. Salas
Alessandra Moltalbano

Frontiers in Chemistry

doi 10.3389/fchem.2025.1559849

575 views

Review

Published on 29 Jan 2025

4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets

in Medicinal and Pharmaceutical Chemistry

Angel H. Romero
Francisco Delgado

Frontiers in Chemistry

doi 10.3389/fchem.2024.1527946

778 views