Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Perspective

Published on 31 Jan 2024

BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery

in Medicinal and Pharmaceutical Chemistry

Andressa Francielli Bonjorno
Aline Renata Pavan
Guilherme F. S. Fernandes
Cauê Benito Scarim
Daniele Castagnolo
Jean Leandro Dos Santos

Frontiers in Chemistry

doi 10.3389/fchem.2024.1358539

6,514 views
4 citations

Original Research

Published on 31 Jan 2024

Characterization and comparative evaluation of wound healing potential of Ajugarin I and Ajuga bracteosa Wall. ex Benth

in Medicinal and Pharmaceutical Chemistry

Yusra Wasti
Durdana Muntaqua
Muhammad Majid
Iffat Naz
Aroosa Zafar
Safir Ullah Khan
Syeda Tayyaba Batool Kazmi
Tofeeq Ur Rehman
Nadeem Irshad
Humaira Fatima

Frontiers in Chemistry

doi 10.3389/fchem.2023.1325578

2,908 views
4 citations

Original Research

Published on 25 Jan 2024

Pb-214/Bi-214-TCMC-Trastuzumab inhibited growth of ovarian cancer in preclinical mouse models

in Medicinal and Pharmaceutical Chemistry

Abdullah Metebi
Nathan Kauffman
Lu Xu
Satyendra Kumar Singh
Chelsea Nayback
Jinda Fan
Nathan Johnson
John Diemer
Terry Grimm
Mike Zamiara

Frontiers in Chemistry

doi 10.3389/fchem.2023.1322773

4,660 views
3 citations

Review

Published on 22 Jan 2024

Aconitine and its derivatives: bioactivities, structure-activity relationships and preliminary molecular mechanisms

in Medicinal and Pharmaceutical Chemistry

Pengyu Zhao
Ye Tian
Yuefei Geng
Chenjuan Zeng
Xiuying Ma
Jie Kang
Lin Lu
Xin Zhang
Bo Tang
Funeng Geng

Frontiers in Chemistry

doi 10.3389/fchem.2024.1339364

5,580 views
8 citations

Original Research

Published on 22 Jan 2024

Integrating computational methods guided the discovery of phytochemicals as potential Pin1 inhibitors for cancer: pharmacophore modeling, molecular docking, MM-GBSA calculations and molecular dynamics studies

in Medicinal and Pharmaceutical Chemistry

Abdulrahim A. Alzain
Fatima A. Elbadwi
Tagyedeen H. Shoaib
Asmaa E. Sherif
Wadah Osman
Ahmed Ashour
Gamal A. Mohamed
Sabrin R. M. Ibrahim
Eun Joo Roh
Ahmed H. E. Hassan

Frontiers in Chemistry

doi 10.3389/fchem.2024.1339891

4,678 views
4 citations

Original Research

Published on 19 Jan 2024

Origanum majorana L. polyphenols: in vivo antiepileptic effect, in silico evaluation of their bioavailability, and interaction with the NMDA receptor

in Medicinal and Pharmaceutical Chemistry

Amal Amaghnouje
Mohamed Chebaibi
Saeed M. Aldossari
Hazem K. Ghneim
Fatima Ez-zahra Amrati
Imane Es-Safi
Francesca Di Cristo
Anna Calarco
Sanae Achour
Fabrizio Carta

Frontiers in Chemistry

doi 10.3389/fchem.2023.1257769

2,446 views
2 citations

Original Research

Published on 19 Jan 2024

Chemical composition, antioxidant, and antimicrobial properties of Mentha subtomentella: in sight in vitro and in silico analysis

in Medicinal and Pharmaceutical Chemistry

Fatima Brahmi
Nour Eddine Bentouhami
Youssef Rbah
Amine Elbouzidi
Ouafae Mokhtari
Ahmad Mohammad Salamatullah
Samir Ibenmoussa
Mohammed Bourhia
Mohamed Addi
Abdeslam Asehraou

Frontiers in Chemistry

doi 10.3389/fchem.2023.1341704

3,069 views
2 citations

Original Research

Published on 16 Jan 2024

ROS-dependent catalytic mechanism of melatonin metabolism and its application in the measurement of reactive oxygen

in Medicinal and Pharmaceutical Chemistry

Xiangge Tian
Xiaohui Kang
Fei Yan
Lei Feng
Xiaokui Huo
Houli Zhang
Yan Wang
Xia Lv
Xiaochi Ma
Jinsong Yuan

Frontiers in Chemistry

doi 10.3389/fchem.2023.1229199

1,801 views
2 citations

Original Research

Published on 16 Jan 2024

Elucidating the binding mechanism of SARS-CoV-2 NSP6-TBK1 and structure-based designing of phytocompounds inhibitors for instigating the host immune response

in Medicinal and Pharmaceutical Chemistry

Muhammad Suleman
Iqra Ishaq
Haji Khan
Safir Ullah khan
Rehana Masood
Norah A. Albekairi
Abdulrahman Alshammari
Sergio Crovella

Frontiers in Chemistry

doi 10.3389/fchem.2023.1346796

3,275 views
2 citations

Original Research

Published on 11 Jan 2024

Versatile approach towards fully desymmetrized trehalose with a novel set of orthogonal protecting groups

in Medicinal and Pharmaceutical Chemistry

Tomáš Vašíček
Benjamin Arensmeyer
Alessandro Monti
Alla Zamyatina

Frontiers in Chemistry

doi 10.3389/fchem.2023.1332837

1,843 views
1 citation

Editorial

Published on 11 Jan 2024

Editorial: Recent advances in medical radiation technology

in Medicinal and Pharmaceutical Chemistry

Samir Acherar

Frontiers in Chemistry

doi 10.3389/fchem.2024.1360379

1,597 views
1 citation

Review

Published on 10 Jan 2024

Research progress of plant-derived natural products in thyroid carcinoma

in Medicinal and Pharmaceutical Chemistry

Qiujing Du
Weidong Shen

Frontiers in Chemistry

doi 10.3389/fchem.2023.1279384

5,539 views
1 citation

Review

Published on 10 Jan 2024

Recent insights into the functions and mechanisms of antisense RNA: emerging applications in cancer therapy and precision medicine

in Medicinal and Pharmaceutical Chemistry

Shahab Ur Rehman
Numan Ullah
Zhenbin Zhang
Yongkang Zhen
Aziz-Ud Din
Hengmi Cui
Mengzhi Wang

Frontiers in Chemistry

doi 10.3389/fchem.2023.1335330

5,178 views
11 citations

Original Research

Published on 10 Jan 2024

Dual COX-2/5-LOX inhibitors from Zanthoxylum simulans inhibit gastric cancer cells by cross-mediating thyroid, estrogen, and oxytocin signaling pathways

in Medicinal and Pharmaceutical Chemistry

Yong-Qiang Tian
Jing Liu
Peng Cheng
Jian Zou
Hui-Fang Xu
Xin-Hua Shi
Yi-Sheng Zhang
Ling Mei

Frontiers in Chemistry

doi 10.3389/fchem.2023.1287570

2,401 views
3 citations

Original Research

Published on 08 Jan 2024

Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome

in Medicinal and Pharmaceutical Chemistry

Pedro M. P. Fernandes
Romina A. Guedes
Bruno L. Victor
Jorge A. R. Salvador
Rita C. Guedes

Frontiers in Chemistry

doi 10.3389/fchem.2023.1322628

2,009 views
1 citation

Original Research

Published on 03 Jan 2024

Antioxidant and anticholinesterase properties of Echinometra mathaei and Ophiocoma erinaceus venoms from the Persian Gulf

in Medicinal and Pharmaceutical Chemistry

Hamideh Dehghani
Marzieh Rashedinia
Gholamhossein Mohebbi
Amir Vazirizadeh
Neda Baghban

Frontiers in Chemistry

doi 10.3389/fchem.2023.1332921

3,179 views
4 citations