Original Research

Published on 04 Sep 2018

Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin

in Chemical Biology

Sarah Spreckelmeyer
Margot van der Zee
Benoît Bertrand
Ewen Bodio
Stefan Stürup
Angela Casini

Frontiers in Chemistry

doi 10.3389/fchem.2018.00377

4,892 views
21 citations

Original Research

Published on 03 Sep 2018

Synthesis and Characterization of Oligothiophene–Porphyrin-Based Molecules That Can Be Utilized for Optical Assignment of Aggregated Amyloid-β Morphotypes

in Chemical Biology

Katriann Arja
Mathias Elgland
K. Peter R. Nilsson

Frontiers in Chemistry

doi 10.3389/fchem.2018.00391

3,670 views
7 citations

Original Research

Published on 24 Aug 2018

In silico Description of LAT1 Transport Mechanism at an Atomistic Level

in Chemical Biology

Luca Palazzolo
Chiara Parravicini
Tommaso Laurenzi
Uliano Guerrini
Cesare Indiveri
Elisabetta Gianazza
Ivano Eberini

Frontiers in Chemistry

doi 10.3389/fchem.2018.00350

6,883 views
13 citations

Original Research

Published on 21 Aug 2018

Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development

in Chemical Biology

Eszter Ostorhazi
Ralf Hoffmann
Nicole Herth
John D. Wade
Carl N. Kraus
Laszlo Otvos Jr.

Frontiers in Chemistry

doi 10.3389/fchem.2018.00359

4,313 views
20 citations

Original Research

Published on 15 Aug 2018

New Properties of a Bioinspired Pyridine Benzimidazole Compound as a Novel Differential Staining Agent for Endoplasmic Reticulum and Golgi Apparatus in Fluorescence Live Cell Imaging

in Chemical Biology

Felipe M. Llancalahuen
Juan A. Fuentes
Alexander Carreño
César Zúñiga
Dayán Páez-Hernández
Manuel Gacitúa
Rubén Polanco
Marcelo D. Preite
Ramiro Arratia-Pérez
Carolina Otero

Frontiers in Chemistry

doi 10.3389/fchem.2018.00345

5,028 views
11 citations

Original Research

Published on 14 Aug 2018

Synergy Between Proline-Rich Antimicrobial Peptides and Small Molecule Antibiotics Against Selected Gram-Negative Pathogens in vitro and in vivo

in Chemical Biology

Laszlo Otvos Jr.
Eszter Ostorhazi
Dora Szabo
Steven D. Zumbrun
Lynda L. Miller
Stephanie A. Halasohoris
Puvi D. Desai
Sharon M. Int Veldt
Carl N. Kraus

Frontiers in Chemistry

doi 10.3389/fchem.2018.00309

5,844 views
34 citations

Original Research

Published on 13 Aug 2018

Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets

in Chemical Biology

Fabio de Moliner
Aaron King
Gleiston G. Dias
Guilherme F. de Lima
Carlos A. de Simone
Eufrânio N. da Silva Júnior
Marc Vendrell

Frontiers in Chemistry

doi 10.3389/fchem.2018.00339

4,883 views
19 citations

Original Research

Published on 24 Jul 2018

Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2

in Chemical Biology

Rachel-Ann A. Garibsingh
Nicholas J. Otte
Elias Ndaru
Claire Colas
Christof Grewer
Jeff Holst
Avner Schlessinger

Frontiers in Chemistry

doi 10.3389/fchem.2018.00279

6,187 views
22 citations

Original Research

Published on 04 Jul 2018

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

in Chemical Biology

Rachel A. North
Weixiao Y. Wahlgren
Daniela M. Remus
Mariafrancesca Scalise
Sarah A. Kessans
Elin Dunevall
Elin Claesson
Tatiana P. Soares da Costa
Matthew A. Perugini
S. Ramaswamy

Frontiers in Chemistry

doi 10.3389/fchem.2018.00233

5,581 views
28 citations

Review

Published on 28 Jun 2018

P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?

in Chemical Biology

Chris N. J. Young
Dariusz C. Górecki

Frontiers in Chemistry

doi 10.3389/fchem.2018.00248

12,554 views
72 citations

Original Research

Published on 26 Jun 2018

Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001

in Chemical Biology

Lin Jiang
Hong Pu
Jingxi Xiang
Meng Su
Xiaohui Yan
Dong Yang
Xiangcheng Zhu
Ben Shen
Yanwen Duan
Yong Huang

Frontiers in Chemistry

doi 10.3389/fchem.2018.00254

5,632 views
31 citations

Review

Published on 22 Jun 2018

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

in Chemical Biology

Mariafrancesca Scalise
Michele Galluccio
Lara Console
Lorena Pochini
Cesare Indiveri

Frontiers in Chemistry

doi 10.3389/fchem.2018.00243

49,646 views
221 citations

Mini Review

Published on 21 Jun 2018

The Emerging Role of microRNAs in Aquaporin Regulation

in Chemical Biology

André Gomes
Inês V. da Silva
Cecília M. P. Rodrigues
Rui E. Castro
Graça Soveral

Frontiers in Chemistry

doi 10.3389/fchem.2018.00238

6,623 views
34 citations

Mini Review

Published on 25 May 2018

Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery

in Chemical Biology

Sina Schmidl
Cristina V. Iancu
Jun-yong Choe
Mislav Oreb

Frontiers in Chemistry

doi 10.3389/fchem.2018.00183

5,773 views
17 citations

Original Research

Published on 25 May 2018

Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations

in Chemical Biology

Anna Hucke
Ga Young Park
Oliver B. Bauer
Georg Beyer
Christina Köppen
Dorothea Zeeh
Christoph A. Wehe
Michael Sperling
Rita Schröter
Marta Kantauskaitè

Frontiers in Chemistry

doi 10.3389/fchem.2018.00180

4,721 views
22 citations

Original Research

Published on 27 Apr 2018

Identification of Loop D Domain Amino Acids in the Human Aquaporin-1 Channel Involved in Activation of the Ionic Conductance and Inhibition by AqB011

in Chemical Biology

Mohamad Kourghi
Michael L. De Ieso
Saeed Nourmohammadi
Jinxin V. Pei
Andrea J. Yool

Frontiers in Chemistry

doi 10.3389/fchem.2018.00142

6,262 views
20 citations

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Articles

Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin

Synthesis and Characterization of Oligothiophene–Porphyrin-Based Molecules That Can Be Utilized for Optical Assignment of Aggregated Amyloid-β Morphotypes

In silico Description of LAT1 Transport Mechanism at an Atomistic Level

Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development

New Properties of a Bioinspired Pyridine Benzimidazole Compound as a Novel Differential Staining Agent for Endoplasmic Reticulum and Golgi Apparatus in Fluorescence Live Cell Imaging

Synergy Between Proline-Rich Antimicrobial Peptides and Small Molecule Antibiotics Against Selected Gram-Negative Pathogens in vitro and in vivo

Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets

Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?

Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

The Emerging Role of microRNAs in Aquaporin Regulation

Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery

Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations

Identification of Loop D Domain Amino Acids in the Human Aquaporin-1 Channel Involved in Activation of the Ionic Conductance and Inhibition by AqB011