Frontiers in Chemistry | Chemical Biology

Original Research

Published on 28 Apr 2021

Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs

in Chemical Biology

Annalisa Tito
Antonio Colantuono
Luciano Pirone
Emilia Pedone
Daniela Intartaglia
Giuliana Giamundo
Ivan Conte
Paola Vitaglione
Fabio Apone

Frontiers in Chemistry

doi 10.3389/fchem.2021.638187

46,447 views
82 citations

Mini Review

Published on 23 Apr 2021

Recent Advances on Sorting Methods of High-Throughput Droplet-Based Microfluidics in Enzyme Directed Evolution

in Chemical Biology

Xiaozhi Fu
Yueying Zhang
Qiang Xu
Xiaomeng Sun
Fanda Meng

Frontiers in Chemistry

doi 10.3389/fchem.2021.666867

14,759 views
32 citations

Original Research

Published on 22 Apr 2021

Development of Fluorescent and Biotin Probes Targeting NLRP3

in Chemical Biology

Tim Keuler
Karl Gatterdam
Anil Akbal
Marta Lovotti
Michael Marleaux
Matthias Geyer
Eicke Latz
Michael Gütschow

Frontiers in Chemistry

doi 10.3389/fchem.2021.642273

6,604 views
11 citations

Original Research

Published on 21 Apr 2021

Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens With Different Peripheral Core Presentations

in Chemical Biology

Jon I. Quintana
Sandra Delgado
Reyes Núñez-Franco
F. Javier Cañada
Gonzalo Jiménez-Osés
Jesús Jiménez-Barbero
Ana Ardá

Frontiers in Chemistry

doi 10.3389/fchem.2021.664097

4,033 views
12 citations

Review

Published on 20 Apr 2021

From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation

in Chemical Biology

Carlotta Cecchini
Sara Pannilunghi
Sébastien Tardy
Leonardo Scapozza

Frontiers in Chemistry

doi 10.3389/fchem.2021.672267

49,243 views
115 citations

Review

Published on 15 Apr 2021

Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes

in Chemical Biology

Antonie J. van der Zouwen
Martin D. Witte

Frontiers in Chemistry

doi 10.3389/fchem.2021.644811

8,224 views
13 citations

Original Research

Published on 14 Apr 2021

New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth

in Chemical Biology

Matjaž Weiss
Elena M. Loi
Maša Sterle
Cyril Balsollier
Tihomir Tomašič
Roland J. Pieters
Martina Gobec
Marko Anderluh

Frontiers in Chemistry

doi 10.3389/fchem.2021.666122

5,879 views
9 citations

Original Research

Published on 14 Apr 2021

Improving the Thermostability and Activity of Transaminase From Aspergillus terreus by Charge-Charge Interaction

in Chemical Biology

Jia-Ren Cao
Fang-Fang Fan
Chang-Jiang Lv
Hong-Peng Wang
Ye Li
Sheng Hu
Wei-Rui Zhao
Hai-Bin Chen
Jun Huang
Le-He Mei

Frontiers in Chemistry

doi 10.3389/fchem.2021.664156

9,235 views
34 citations

Original Research

Published on 14 Apr 2021

In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes

in Chemical Biology

Yentl Van Rymenant
Muhammet Tanc
Roos Van Elzen
An Bracke
Olivier De Wever
Koen Augustyns
Anne-Marie Lambeir
Mark Kockx
Ingrid De Meester
Pieter Van Der Veken

Frontiers in Chemistry

doi 10.3389/fchem.2021.640566

8,485 views
15 citations

Mini Review

Published on 13 Apr 2021

Application of the Inverse-Electron-Demand Diels-Alder Reaction for Metabolic Glycoengineering

in Chemical Biology

Lisa Maria Haiber
Markus Kufleitner
Valentin Wittmann

Frontiers in Chemistry

doi 10.3389/fchem.2021.654932

6,944 views
18 citations

Mini Review

Published on 12 Apr 2021

Chemical Glycosylation and Its Application to Glucose Homeostasis-Regulating Peptides

in Chemical Biology

Chaitra Chandrashekar
Mohammed Akhter Hossain
John D. Wade

Frontiers in Chemistry

doi 10.3389/fchem.2021.650025

6,943 views
21 citations

Original Research

Published on 30 Mar 2021

Profiling the Production of Antimicrobial Secondary Metabolites by Xenorhabdus khoisanae J194 Under Different Culturing Conditions

in Chemical Biology

Elzaan Booysen
Marina Rautenbach
Marietjie A. Stander
Leon M. T. Dicks

Frontiers in Chemistry

doi 10.3389/fchem.2021.626653

4,576 views
15 citations

Original Research

Published on 16 Mar 2021

A Metabolomics and Molecular Networking Approach to Elucidate the Structures of Secondary Metabolites Produced by Serratia marcescens Strains

in Chemical Biology

Tanya Clements
Marina Rautenbach
Thando Ndlovu
Sehaam Khan
Wesaal Khan

Frontiers in Chemistry

doi 10.3389/fchem.2021.633870

5,405 views
28 citations

Original Research

Published on 04 Mar 2021

The Abnormal Glycopatterns of Salivary Glycoproteins in Esophageal Squamous Cell Carcinoma Patients

in Chemical Biology

Jian Shu
Jun Ma
Xiameng Ren
Jian Wang
Yan Wang
Kun Zhang
Hanjie Yu
Xiangqian Guo
Zheng Li

Frontiers in Chemistry

doi 10.3389/fchem.2021.637730

4,104 views
12 citations

Original Research

Published on 02 Mar 2021

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation

in Chemical Biology

Mohadeseh Dastpeyman
John A. Karas
Azin Amin
Bradley J. Turner
Fazel Shabanpoor

Frontiers in Chemistry

doi 10.3389/fchem.2021.627329

5,885 views
13 citations

Original Research

Published on 25 Feb 2021

ABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context

in Chemical Biology

Hannah B. L. Jones
Raphael Heilig
Roman Fischer
Benedikt M. Kessler
Adán Pinto-Fernández

Frontiers in Chemistry

doi 10.3389/fchem.2021.640105

8,373 views
22 citations