Frontiers in Chemical Biology

Original Research

Published on 05 Aug 2024

Structural and kinetic characterization of DUSP5 with a Di-phosphorylated tripeptide substrate from the ERK activation loop

Andrea Imhoff
Noreena L. Sweeney
Robert D. Bongard
Raulia Syrlybaeva
Ankan Gupta
Edgar Del Carpio
Marat R. Talipov
Costanza Garcia-Keller
Debbie C. Crans
Ramani Ramchandran

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1385560

1,170 views
2 citations

Original Research

Published on 31 Jul 2024

Generation of lysolipin derivatives by genetic engineering

Helene Robertsen
Sabrina Rohrer
Andreas Kulik
Wolfgang Wohlleben
Yvonne Mast

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1445095

1,021 views

Original Research

Published on 29 Jul 2024

Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants

Jacob L. Capener
James D. Vasta
Vittorio L. Katis
Ani Michaud
Michael T. Beck
Sabrina C. D. Daglish
Sarit Cohen-Kedar
Efrat Shaham Barda
Stefanie Howell
Iris Dotan

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1447622

1,040 views

Original Research

Published on 23 Jul 2024

In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering

Yvett Sosa
Bhav Kapur
Jessica Hurtak
Laura J. Kingsley
Hao Wu
Stefanie Gruber
Herbert Nar
Saad Khattabi
Jesus Seco Moral
Maria Fátima Lucas

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1425501

2,048 views

Original Research

Published on 22 Jul 2024

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

Rick Janssens
Rien van Haperen
Michael van der Reijden
Alex Maas
Jingsong Wang
Frank Grosveld
Dubravka Drabek

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1408621

2,381 views

Mini Review

Published on 12 Jul 2024

The chemistry of Formycin biosynthesis

Nigel G. J. Richards
James H. Naismith

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1428646

972 views

Original Research

Published on 10 Jul 2024

A switch and a failsafe: KatG’s mechanism for preservation of catalase activity using a conformationally dynamic Arg and an active-site Trp

Hui Xu
Jessica R. Kenneson
Laura E. Minton
Douglas C. Goodwin

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1431412

1,318 views

Original Research

Published on 05 Jul 2024

Solution chemistry and anti-proliferative activity against glioblastoma cells of a vanadium(V) complex with two bioactive ligands

Aviva Levina
Gonzalo Scalese
Dinorah Gambino
Debbie C. Crans
Peter A. Lay

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1394645

840 views
4 citations

Original Research

Published on 17 Jun 2024

Development of bioluminescent reporter Trypanosoma cruzi and bioassay for compound screening

Cristina Quiroga
Marcelo Incerti
Diego Benitez
Eduardo Manta
Andrea Medeiros
Marcelo A. Comini

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1423430

1,305 views

Review

Published on 06 Jun 2024

Advances in human glutamine-hydrolyzing synthetases and their therapeutic potential

Wen Zhu
Alanya J. Nardone
Lucciano A. Pearce

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1410435

2,023 views
1 citation

Mini Review

Published on 30 May 2024

Keto-enol tautomerism in the development of new drugs

Ana Paula Araujo de Oliveira
Camila Anchau Wegermann
Ana Maria Da Costa Ferreira

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1400642

2,683 views

Original Research

Published on 22 May 2024

Effect of pH on the thermostability and redox properties of cytochrome c552 from Wolinella succinogenes

Vitor H. Mordido
Marta S. P. Carepo
Cristina M. Cordas
Navendu Paul
Jörg Simon
Isabel Moura
Sofia R. Pauleta

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1398105

907 views

Mini Review

Published on 09 May 2024

A mini review of mycotoxin’s occurrence in food in South America in the last 5 years: research gaps and challenges in a climate change era

Claudia Foerster
Andrea Müller-Sepúlveda
Marina Venturini Copetti
Andrea Alejandra Arrúa
Liliam Monsalve
María Laura Ramirez
Adriana M. Torres

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1400481

2,250 views
1 citation

Original Research

Published on 07 May 2024

An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme

Lauren B. Coco
Caren L. Freel Meyers

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1389620

964 views

Review

Published on 25 Apr 2024

A review of hydrazide-hydrazone metal complexes’ antitumor potential

Nádia Ribeiro
Isabel Correia

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1398873

3,432 views
5 citations

Mini Review

Published on 10 Apr 2024

Recent food alerts and analytical advances related to the contamination of tropane and pyrrolizidine alkaloids in food

Natalia Casado
Judith Gañán
Sonia Morante-Zarcero
Isabel Sierra

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1360027

1,575 views
3 citations

51 Publications

Volume 3 - 2024

Structural and kinetic characterization of DUSP5 with a Di-phosphorylated tripeptide substrate from the ERK activation loop

Generation of lysolipin derivatives by genetic engineering

Development of SYK NanoBRET cellular target engagement assays for gain–of–function variants

In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering

Generation and preclinical evaluation of a human heavy-chain-only antibody recognizing the membrane-bound tumor-associated antigen mesothelin

The chemistry of Formycin biosynthesis

A switch and a failsafe: KatG’s mechanism for preservation of catalase activity using a conformationally dynamic Arg and an active-site Trp

Solution chemistry and anti-proliferative activity against glioblastoma cells of a vanadium(V) complex with two bioactive ligands

Development of bioluminescent reporter Trypanosoma cruzi and bioassay for compound screening

Advances in human glutamine-hydrolyzing synthetases and their therapeutic potential

Keto-enol tautomerism in the development of new drugs

Effect of pH on the thermostability and redox properties of cytochrome c552 from Wolinella succinogenes

A mini review of mycotoxin’s occurrence in food in South America in the last 5 years: research gaps and challenges in a climate change era

An activity-based probe for antimicrobial target DXP synthase, a thiamin diphosphate-dependent enzyme

A review of hydrazide-hydrazone metal complexes’ antitumor potential

Recent food alerts and analytical advances related to the contamination of tropane and pyrrolizidine alkaloids in food