Frontiers in Bioengineering and Biotechnology | Organoids and Organ-On-A-Chip

Review

Published on 01 Apr 2025

Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier

in Organoids and Organ-On-A-Chip

Nina Truong
Abir Zahra
Ryan C. V. Lintao
Rahul Chauhan
Giovana Fernanda Bento
Manuel Vidal Jr.
Sungjin Kim
Po Yi Lam
Thomas Conrads
Kelly Conrads

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1568389

289 views

Review

Published on 31 Mar 2025

Host-microbe-cancer interactions on-a-chip

in Organoids and Organ-On-A-Chip

Mauricio G. C. Sousa
Danielle S. K. Brasino
Madeline Krieger
Duygu A. Dindar
Rebekka Duhen
Zhenzhen Zhang
Cristiane Miranda Franca
Luiz E. Bertassoni

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1505963

254 views

Original Research

Accepted on 26 Mar 2025

A hybrid computational model of cancer spheroid growth with ribose-induced collagen stiffening

in Organoids and Organ-On-A-Chip

Margherita Botticelli
John Metzcar
Thomas Phillips
Susan Cox
Pradeep Keshavanarayana
Fabian Spill

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1515962

Mini Review

Accepted on 21 Mar 2025

Developments in gastrointestinal organoid cultures to recapitulate tissue environments

in Organoids and Organ-On-A-Chip

Madeline Kuhn
Emma A Wolcott
Ellen M Langer

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1521044

Perspective

Published on 20 Mar 2025

Bioengineering ethics for the age of microphysiological systems

in Organoids and Organ-On-A-Chip

Maxence Gaillard

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1497060

349 views

Review

Published on 11 Mar 2025

Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling

in Organoids and Organ-On-A-Chip

Lito Papamichail
Lena S. Koch
Devin Veerman
Kerensa Broersen
Andries D. van der Meer

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1515340

1,146 views

Mini Review

Published on 27 Jan 2025

In silico modelling of organ-on-a-chip devices: an overview

in Organoids and Organ-On-A-Chip

Yue Wang
Lucia Marucci
Martin E. Homer

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1520795

1,063 views

Review

Published on 07 Jan 2025

The utilisation of biliary organoids for biomedical applications

in Organoids and Organ-On-A-Chip

Zhongwen Lei
Yijun Yang
Yang Xiang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1501829

1,054 views

Review

Published on 07 Jan 2025

Microfluidic organ-on-chip systems for periodontal research: advances and future directions

in Organoids and Organ-On-A-Chip

Gopu Sriram
Hardik Makkar

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1490453

1,771 views

Methods

Published on 18 Dec 2024

Rapid and reproducible generation of glioblastoma spheroids for high-throughput drug screening

in Organoids and Organ-On-A-Chip

Christian Bach
Annegret Glasow
Rainer Baran-Schmidt
Henry Oppermann
Christoph Bach
Jürgen Meixensberger
Erdem Güresir
Frank Gaunitz

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1471012

924 views

Original Research

Published on 16 Dec 2024

Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model

in Organoids and Organ-On-A-Chip

Angelo Massaro
Cecilia Villegas Novoa
Yuli Wang
Nancy L. Allbritton

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1506976

1,375 views
1 citation

Original Research

Published on 11 Nov 2024

Non-invasive real-time investigation of colorectal cells tight junctions by Raman microspectroscopy analysis combined with machine learning algorithms for organ-on-chip applications

in Organoids and Organ-On-A-Chip

A. Calogiuri
D. Bellisario
E. Sciurti
L. Blasi
V. Esposito
F. Casino
P. Siciliano
L. Francioso

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1458404

1,235 views

Original Research

Published on 08 Oct 2024

Assessing the metastatic potential of circulating tumor cells using an organ-on-chip model

in Organoids and Organ-On-A-Chip

Karin F. Schmid
Soheila Zeinali
Susanne K. Moser
Christelle Dubey
Sabine Schneider
Haibin Deng
Simon Haefliger
Thomas M. Marti
Olivier T. Guenat

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1457884

1,836 views

Original Research

Published on 02 Oct 2024

A millifluidic bioreactor allows the long term culture of primary lymphocytes or CD34+ hematopoietic cells while allowing the detection of tumorigenic expansion

in Organoids and Organ-On-A-Chip

Paolo Ritter
Stefania Oliveto
Chiara Cordiglieri
Alessandra Fasciani
Christian Andrea Di Buduo
Lucrezia della Volpe
Alberto Bocconi
Claudio Conci
Carolina Paula Miguel
Raffaella Di Micco

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1388312

1,821 views

Review

Published on 02 Oct 2024

Tumor-on-chip platforms for breast cancer continuum concept modeling

in Organoids and Organ-On-A-Chip

Anca-Narcisa Neagu
Danielle Whitham
Pathea Bruno
Nicholas Versaci
Peter Biggers
Costel C. Darie

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1436393

2,419 views

Review

Published on 25 Sep 2024

Improving tumor microenvironment assessment in chip systems through next-generation technology integration

in Organoids and Organ-On-A-Chip

Daniela Gaebler
Stephanie J. Hachey
Christopher C. W. Hughes

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1462293

2,204 views