Review

Published on 26 Nov 2020

Cell-Based Therapy Manufacturing in Stirred Suspension Bioreactor: Thoughts for cGMP Compliance

in Cell and Gene Therapy

Suman C. Nath
Lane Harper
Derrick E. Rancourt

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.599674

12,426 views
21 citations

Original Research

Published on 24 Nov 2020

A Machine Learning Approach for Tracing Tumor Original Sites With Gene Expression Profiles

in Cell and Gene Therapy

Xin Liang
Wen Zhu
Bo Liao
Bo Wang
Jialiang Yang
Xiaofei Mo
Ruixi Li

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.607126

2,562 views
6 citations

Review

Published on 19 Nov 2020

Non-viral Gene Delivery Methods for Bone and Joints

in Cell and Gene Therapy

Benjamin Gantenbein
Shirley Tang
Julien Guerrero
Natalia Higuita-Castro
Ana I. Salazar-Puerta
Andreas S. Croft
Amiq Gazdhar
Devina Purmessur

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.598466

14,233 views
42 citations

Original Research

Published on 19 Nov 2020

Development of Site-Specific PEGylated Granulocyte Colony Stimulating Factor With Prolonged Biological Activity

in Cell and Gene Therapy

Monika Kumari
Girish Sahni
Sonal Datta

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.572077

4,839 views
7 citations

Original Research

Published on 16 Nov 2020

De novo Vessel Formation Through Cross-Talk of Blood-Derived Cells and Mesenchymal Stromal Cells in the Absence of Pre-existing Vascular Structures

in Cell and Gene Therapy

Beate M. Rüger
Tanja Buchacher
Eva-Maria Dauber
Markus Pasztorek
Pavel Uhrin
Michael B. Fischer
Johannes M. Breuss
Gerda C. Leitner

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.602210

10,856 views
9 citations

Original Research

Published on 13 Nov 2020

Physioxia Stimulates Extracellular Matrix Deposition and Increases Mechanical Properties of Human Chondrocyte-Derived Tissue-Engineered Cartilage

in Cell and Gene Therapy

James E. Dennis
George Adam Whitney
Jyoti Rai
Russell J. Fernandes
Thomas J. Kean

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.590743

4,159 views
20 citations

Original Research

Published on 29 Oct 2020

Regulation of Ptch1 by miR-342-5p and FoxO3 Induced Autophagy Involved in Renal Fibrosis

in Cell and Gene Therapy

Simin Tang
Yi Wang
Guiling Xie
Wenjun Li
Yanna Chen
Jinshu Liang
Pei Liu
Fuhu Song
Jun Zhou

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.583318

4,775 views
15 citations

Correction

Published on 26 Oct 2020

Corrigendum: Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and Rejuvenation

in Cell and Gene Therapy

Weiping Lin
Liangliang Xu
Gang Li

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.598323

1,726 views

Opinion

Published on 15 Oct 2020

PHP.B/eB Vectors Bring New Successes to Gene Therapy for Brain Diseases

in Cell and Gene Therapy

Robin Reynaud-Dulaurier
Michael Decressac

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.582979

5,458 views
6 citations

Original Research

Published on 14 Oct 2020

Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction

in Cell and Gene Therapy

Clara Sanjurjo-Rodriguez
Ala Altaie
Simon Mastbergen
Thomas Baboolal
Tim Welting
Floris Lafeber
Hemant Pandit
Dennis McGonagle
Elena Jones

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.579751

6,425 views
20 citations

Original Research

Published on 06 Oct 2020

Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

in Cell and Gene Therapy

William A. Lackington
Maria Antonia Gomez-Sierra
Arlyng González-Vázquez
Fergal J. O’Brien
Martin J. Stoddart
Keith Thompson

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.582012

4,119 views
14 citations

Original Research

Published on 25 Sep 2020

Characterization and Chondroprotective Effects of Extracellular Vesicles From Plasma- and Serum-Based Autologous Blood-Derived Products for Osteoarthritis Therapy

in Cell and Gene Therapy

Alexander Otahal
Karina Kramer
Olga Kuten-Pella
René Weiss
Christoph Stotter
Zsombor Lacza
Viktoria Weber
Stefan Nehrer
Andrea De Luna

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.584050

13,539 views
36 citations

Original Research

Published on 28 Aug 2020

Aggrecan and COMP Improve Periosteal Chondrogenesis by Delaying Chondrocyte Hypertrophic Maturation

in Cell and Gene Therapy

Marjolein M. J. Caron
Maarten P. F. Janssen
Laura Peeters
Dominik R. Haudenschild
Andy Cremers
Don A. M. Surtel
Lodewijk W. van Rhijn
Pieter J. Emans
Tim J. M. Welting

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.01036

5,910 views
27 citations

Original Research

Published on 05 Aug 2020

Efficient Delivery of Transducing Polymer Nanoparticles for Gene-Mediated Induction of Osteogenesis for Bone Regeneration

in Cell and Gene Therapy

Aveen R. Jalal
James E. Dixon

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.00849

4,353 views
12 citations

Original Research

Published on 31 Jul 2020

Bovine Milk Extracellular Vesicles Are Osteoprotective by Increasing Osteocyte Numbers and Targeting RANKL/OPG System in Experimental Models of Bone Loss

in Cell and Gene Therapy

Marina C. Oliveira
Bartijn C. H. Pieters
Polianna B. Guimarães
Letícia F. Duffles
Joyce E. Heredia
Ana L. M. Silveira
Amanda C. C. Oliveira
Mauro M. Teixeira
Adaliene V. M. Ferreira
Tarcilia A. Silva

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.00891

5,117 views
23 citations

Correction

Published on 31 Jul 2020

Corrigendum: Immobilization of Growth Factors for Cell Therapy Manufacturing

in Cell and Gene Therapy

Daniela Enriquez-Ochoa
Pedro Robles-Ovalle
Karla Mayolo-Deloisa
Marion E. G. Brunck

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.00821

1,757 views
2 citations

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Articles

Cell-Based Therapy Manufacturing in Stirred Suspension Bioreactor: Thoughts for cGMP Compliance

A Machine Learning Approach for Tracing Tumor Original Sites With Gene Expression Profiles

Non-viral Gene Delivery Methods for Bone and Joints

Development of Site-Specific PEGylated Granulocyte Colony Stimulating Factor With Prolonged Biological Activity

De novo Vessel Formation Through Cross-Talk of Blood-Derived Cells and Mesenchymal Stromal Cells in the Absence of Pre-existing Vascular Structures

Physioxia Stimulates Extracellular Matrix Deposition and Increases Mechanical Properties of Human Chondrocyte-Derived Tissue-Engineered Cartilage

Regulation of Ptch1 by miR-342-5p and FoxO3 Induced Autophagy Involved in Renal Fibrosis

Corrigendum: Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and Rejuvenation

PHP.B/eB Vectors Bring New Successes to Gene Therapy for Brain Diseases

Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction

Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Characterization and Chondroprotective Effects of Extracellular Vesicles From Plasma- and Serum-Based Autologous Blood-Derived Products for Osteoarthritis Therapy

Aggrecan and COMP Improve Periosteal Chondrogenesis by Delaying Chondrocyte Hypertrophic Maturation

Efficient Delivery of Transducing Polymer Nanoparticles for Gene-Mediated Induction of Osteogenesis for Bone Regeneration

Bovine Milk Extracellular Vesicles Are Osteoprotective by Increasing Osteocyte Numbers and Targeting RANKL/OPG System in Experimental Models of Bone Loss

Corrigendum: Immobilization of Growth Factors for Cell Therapy Manufacturing