Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Original Research

Published on 27 Aug 2019

Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational Molecular Modeling and in vitro Assay

in Cellular and Molecular Mechanisms of Brain-aging

Aimi Syamima Abdul Manap
Amelia Cheng Wei Tan
Weng Hhin Leong
Adeline Yoke Yin Chia
Shantini Vijayabalan
Aditya Arya
Eng Hwa Wong
Farzana Rizwan
Umesh Bindal
Shajan Koshy

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00206

18,029 views
78 citations

Original Research

Published on 31 Jul 2019

Exploring the Mitochondrial Degradome by the TAILS Proteomics Approach in a Cellular Model of Parkinson’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Marta Lualdi
Maurizio Ronci
Mara Zilocchi
Federica Corno
Emily S. Turilli
Mauro Sponchiado
Antonio Aceto
Tiziana Alberio
Mauro Fasano

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00195

5,739 views
11 citations

Original Research

Published on 31 Jul 2019

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task

in Cellular and Molecular Mechanisms of Brain-aging

Jana Lubec
Roman Smidak
Jovana Malikovic
Daniel Daba Feyissa
Volker Korz
Harald Höger
Gert Lubec

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00198

4,562 views
21 citations

Mini Review

Published on 30 Jul 2019

Age-Related Functional and Expressional Changes in Efflux Pathways at the Blood-Brain Barrier

in Cellular and Molecular Mechanisms of Brain-aging

Franciska Erdő
Péter Krajcsi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00196

7,687 views
65 citations

Original Research

Published on 25 Jul 2019

Endogenous HCN Channels Modulate the Firing Activity of Globus Pallidus Neurons in Parkinsonian Animals

in Cellular and Molecular Mechanisms of Brain-aging

Xiao-Meng Hao
Rong Xu
An-Qi Chen
Feng-Jiao Sun
Ying Wang
Hong-Xia Liu
Hua Chen
Yan Xue
Lei Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00190

4,063 views
13 citations

Original Research

Published on 17 Jul 2019

Identification of the Potential Key Long Non-coding RNAs in Aged Mice With Postoperative Cognitive Dysfunction

in Cellular and Molecular Mechanisms of Brain-aging

Ming Li
Chan Chen
Weiyi Zhang
Rui Gao
Qiao Wang
Hai Chen
Shu Zhang
Xiaobo Mao
Mathis Leblanc
Adam Behensky

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00181

5,649 views
25 citations

Original Research

Published on 12 Jul 2019

Neuroprotective Effects of Kinin B2 Receptor in Organotypic Hippocampal Cultures of Middle-Aged Mice

in Cellular and Molecular Mechanisms of Brain-aging

Mariana Toricelli
Sebastiana Ribeiro Evangelista
Larissa Rolim Oliveira
Tania Araujo Viel
Hudson Sousa Buck

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00168

3,352 views
5 citations

Original Research

Published on 04 Jul 2019

3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain

in Cellular and Molecular Mechanisms of Brain-aging

Shereen Nizari
Roxana O. Carare
Ignacio A. Romero
Cheryl A. Hawkes

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00172

5,994 views
20 citations

Review

Published on 02 Jul 2019

Decoding the Role of Platelets and Related MicroRNAs in Aging and Neurodegenerative Disorders

in Cellular and Molecular Mechanisms of Brain-aging

Yolanda Espinosa-Parrilla
Christian Gonzalez-Billault
Eduardo Fuentes
Ivan Palomo
Marcelo Alarcón

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00151

12,361 views
38 citations

Original Research

Published on 26 Jun 2019

Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice

in Cellular and Molecular Mechanisms of Brain-aging

Guoqiang Wan
Lingchao Ji
Thomas Schrepfer
Sihao Gong
Guo-Peng Wang
Gabriel Corfas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00156

6,752 views
26 citations

Original Research

Published on 19 Jun 2019

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Bérénice Hatat
Samir Yahiaoui
Cédric Lecoutey
Audrey Davis
Thomas Freret
Michel Boulouard
Sylvie Claeysen
Christophe Rochais
Patrick Dallemagne

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00148

4,001 views
24 citations

Hypothesis and Theory

Published on 13 Jun 2019

Involvement of microRNA-34a in Age-Related Susceptibility to Oxidative Stress in ARPE-19 Cells by Targeting the Silent Mating Type Information Regulation 2 Homolog 1/p66shc Pathway: Implications for Age-Related Macular Degeneration

in Cellular and Molecular Mechanisms of Brain-aging

Nianting Tong
Rong Jin
Zhanyu Zhou
Xingwei Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00137

4,092 views
20 citations

Mini Review

Published on 11 Jun 2019

Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Jennifer M. Hafycz
Nirinjini N. Naidoo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00140

7,319 views
19 citations

Original Research

Published on 31 May 2019

Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons

in Cellular and Molecular Mechanisms of Brain-aging

Sandra Cristina Zárate
Marianela Evelyn Traetta
Martín Gabriel Codagnone
Adriana Seilicovich
Analía Gabriela Reinés

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00123

22,023 views
60 citations

Review

Published on 24 Apr 2019

Gi/o-Protein Coupled Receptors in the Aging Brain

in Cellular and Molecular Mechanisms of Brain-aging

Patrícia G. de Oliveira
Marta L. S. Ramos
António J. Amaro
Roberto A. Dias
Sandra I. Vieira

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00089

49,262 views
71 citations

Original Research

Published on 26 Mar 2019

Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Qinghua Zeng
Zhimin Long
Min Feng
Yueyang Zhao
Shifang Luo
Kejian Wang
Yingxiong Wang
Guang Yang
Guiqiong He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00062

9,333 views
60 citations