Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Original Research

Published on 12 Nov 2020

Longitudinal Characterization of Transcriptomic, Functional, and Morphological Features in Human iPSC-Derived Neurons and Their Application to Investigate Translational Progranulin Disease Biology

in Cellular and Molecular Mechanisms of Brain-aging

Gaëlle Robin
J. Corey Evans
David N. Hauser
Paul Wren
Andreas Zembrzycki

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.576678

7,779 views
5 citations

Original Research

Published on 10 Nov 2020

Identification of Caffeic Acid Phenethyl Ester (CAPE) as a Potent Neurodifferentiating Natural Compound That Improves Cognitive and Physiological Functions in Animal Models of Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Arpita Konar
Rajkumar Singh Kalra
Anupama Chaudhary
Aashika Nayak
Kanive P. Guruprasad
Kapaettu Satyamoorthy
Yoshiyuki Ishida
Keiji Terao
Sunil C. Kaul
Renu Wadhwa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.561925

6,553 views
16 citations

Original Research

Published on 09 Nov 2020

Satellite Glial Cells of the Dorsal Root Ganglion: A New “Guest/Physiopathological Target” in ALS

in Cellular and Molecular Mechanisms of Brain-aging

María Ruiz-Soto
Javier Riancho
Olga Tapia
Miguel Lafarga
María T. Berciano

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.595751

5,507 views
12 citations

Editorial

Published on 30 Oct 2020

Editorial: Intramural Vascular Cells: Key Therapeutic Targets for Vascular Cognitive Impairment

in Cellular and Molecular Mechanisms of Brain-aging

Satoshi Saito
JoAnne McLaurin
Roxana Octavia Carare

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.615780

2,235 views
1 citation

Brief Research Report

Published on 28 Oct 2020

Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau

in Cellular and Molecular Mechanisms of Brain-aging

Shannon N. Leslie
Dibyadeep Datta
Kyle R. Christensen
Christopher H. van Dyck
Amy F. T. Arnsten
Angus C. Nairn

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.576723

4,036 views
15 citations

Original Research

Published on 06 Oct 2020

Ofloxacin as a Disruptor of Actin Aggresome “Hirano Bodies”: A Potential Repurposed Drug for the Treatment of Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Samridhi Pathak
Haifa Parkar
Sarita Tripathi
Avinash Kale

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.591579

5,022 views
5 citations

Review

Published on 06 Oct 2020

Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Jessica Tittelmeier
Eliana Nachman
Carmen Nussbaum-Krammer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.581374

21,454 views
77 citations

Review

Published on 06 Oct 2020

Neurogranin: A Potential Biomarker of Neurological and Mental Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Yang Xiang
Jiayan Xin
Weidong Le
Yongjian Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.584743

20,390 views
71 citations

Editorial

Published on 23 Sep 2020

Editorial: Modulating Glial Cells Phenotype: New Findings and Therapies

in Cellular and Molecular Mechanisms of Brain-aging

María José Bellini
Yolanda Diz-Chaves
Alberto Javier Ramos

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.594870

2,188 views
1 citation

Original Research

Published on 18 Sep 2020

The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons

in Cellular and Molecular Mechanisms of Brain-aging

Emily Machiela
Ritika Jeloka
Nicholas S. Caron
Shagun Mehta
Mandi E. Schmidt
Helen J. E. Baddeley
Colton M. Tom
Nalini Polturi
Yuanyun Xie
Virginia B. Mattis

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.524369

8,693 views
25 citations

Original Research

Published on 15 Sep 2020

Changes in Metabolism and Proteostasis Drive Aging Phenotype in Aplysia californica Sensory Neurons

in Cellular and Molecular Mechanisms of Brain-aging

Nicholas S. Kron
Michael C. Schmale
Lynne A. Fieber

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.573764

4,582 views
11 citations

Mini Review

Published on 11 Sep 2020

The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging

in Cellular and Molecular Mechanisms of Brain-aging

Francisco Muñoz-Carvajal
Mario Sanhueza

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.581849

14,681 views
47 citations

Mini Review

Published on 03 Sep 2020

Redox Post-translational Modifications of Protein Thiols in Brain Aging and Neurodegenerative Conditions—Focus on S-Nitrosation

in Cellular and Molecular Mechanisms of Brain-aging

Mattéa J. Finelli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.00254

8,950 views
28 citations

Review

Published on 02 Sep 2020

Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease

in Cellular and Molecular Mechanisms of Brain-aging

Caroline L. Benn
Lee A. Dawson

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.00242

10,887 views
42 citations

Review

Published on 27 Aug 2020

Secreted Chaperones in Neurodegeneration

in Cellular and Molecular Mechanisms of Brain-aging

Kriti Chaplot
Timothy S. Jarvela
Iris Lindberg

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.00268

9,653 views
44 citations

Brief Research Report

Published on 18 Aug 2020

Huntingtin Aggregates in the Olfactory Bulb in Huntington’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Blake Highet
Birger Victor Dieriks
Helen C. Murray
Richard L. M. Faull
Maurice A. Curtis

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2020.00261

4,698 views
22 citations