Original Research

Published on 28 Sep 2021

Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept

in Cellular and Molecular Mechanisms of Brain-aging

Theresa Lüth
Kobi Wasner
Christine Klein
Susen Schaake
Ronnie Tse
Sandro L. Pereira
Joshua Laß
Lasse Sinkkonen
Anne Grünewald
Joanne Trinh

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.713084

8,129 views
14 citations

Systematic Review

Published on 21 Sep 2021

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

in Cellular and Molecular Mechanisms of Brain-aging

Mohammad Reza Asadi
Mehdi Hassani
Shiva Kiani
Hani Sabaie
Marziyeh Sadat Moslehian
Mohammad Kazemi
Soudeh Ghafouri-Fard
Mohammad Taheri
Maryam Rezazadeh

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.709568

6,274 views
26 citations

Review

Published on 20 Sep 2021

Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node

in Cellular and Molecular Mechanisms of Brain-aging

Yang Fang
Xifeng Wang
Danying Yang
Yimei Lu
Gen Wei
Wen Yu
Xing Liu
Qingcui Zheng
Jun Ying
Fuzhou Hua

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.738686

6,636 views
28 citations

Original Research

Published on 17 Sep 2021

Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

in Cellular and Molecular Mechanisms of Brain-aging

Claudia Salcedo
Jens V. Andersen
Kasper Tore Vinten
Lars H. Pinborg
Helle S. Waagepetersen
Kristine K. Freude
Blanca I. Aldana

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.736580

9,232 views
40 citations

Review

Published on 07 Sep 2021

Mitochondrial Dynamics: A Potential Therapeutic Target for Ischemic Stroke

in Cellular and Molecular Mechanisms of Brain-aging

Xiangyue Zhou
Hanmin Chen
Ling Wang
Cameron Lenahan
Lifei Lian
Yibo Ou
Yue He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.721428

10,570 views
46 citations

Original Research

Published on 30 Aug 2021

Efficacy of Δ9 -Tetrahydrocannabinol (THC) Alone or in Combination With a 1:1 Ratio of Cannabidiol (CBD) in Reversing the Spatial Learning Deficits in Old Mice

in Cellular and Molecular Mechanisms of Brain-aging

Prakash Nidadavolu
Andras Bilkei-Gorzo
Michael Krämer
Britta Schürmann
Michela Palmisano
Eva C. Beins
Burkhard Madea
Andreas Zimmer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.718850

9,198 views
13 citations

Original Research

Published on 23 Aug 2021

Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice

in Cellular and Molecular Mechanisms of Brain-aging

Helena Nascimento Malerba
Arthur Antonio Ruiz Pereira
Marcela Favoretto Pierrobon
Guilherme Souza Abrao
Mariana Toricelli
Eliana Hiromi Akamine
Hudson Sousa Buck
Tania Araujo Viel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.681498

3,066 views
8 citations

Original Research

Published on 13 Aug 2021

Prostaglandin E2 Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Amanda C. Rosehart
Thomas A. Longden
Nick Weir
Jackson T. Fontaine
Anne Joutel
Fabrice Dabertrand

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.695965

4,301 views
13 citations

Original Research

Published on 12 Aug 2021

Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers

in Cellular and Molecular Mechanisms of Brain-aging

Sumonto Mitra
Giorgio Turconi
Taher Darreh-Shori
Kärt Mätlik
Matilde Aquilino
Maria Eriksdotter
Jaan-Olle Andressoo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.714186

4,367 views
9 citations

Original Research

Published on 06 Aug 2021

Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice

in Cellular and Molecular Mechanisms of Brain-aging

Jian-Wei Zhu
Wei-Qiang Jia
Hui Zhou
Yi-Fei Li
Ming-Ming Zou
Zhao-Tao Wang
Bing-Shan Wu
Ru-Xiang Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.697494

4,570 views
8 citations

Original Research

Published on 04 Aug 2021

Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen’s Critical Window

in Cellular and Molecular Mechanisms of Brain-aging

Puja Sinha
Asha Rani
Ashok Kumar
Alberto Riva
Jason Orr Brant
Thomas C. Foster

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.717032

3,743 views
4 citations

Review

Published on 03 Aug 2021

Understanding Intra-Species and Inter-Species Prion Conversion and Zoonotic Potential Using Protein Misfolding Cyclic Amplification

in Cellular and Molecular Mechanisms of Brain-aging

Alexander H. Peden
Suzanne Suleiman
Marcelo A. Barria

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.716452

4,923 views
11 citations

Mini Review

Published on 02 Aug 2021

In vivo Direct Conversion of Astrocytes to Neurons Maybe a Potential Alternative Strategy for Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Youcui Wang
Xiaoqin Zhang
Fenghua Chen
Ning Song
Junxia Xie

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.689276

11,928 views
14 citations

Original Research

Published on 30 Jul 2021

A Shift in Tissue Stiffness During Hippocampal Maturation Correlates to the Pattern of Neurogenesis and Composition of the Extracellular Matrix

in Cellular and Molecular Mechanisms of Brain-aging

Youngjae Ryu
Misato Iwashita
Wonyoung Lee
Kenji Uchimura
Yoichi Kosodo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.709620

6,046 views
27 citations

Brief Research Report

Published on 30 Jul 2021

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport

in Cellular and Molecular Mechanisms of Brain-aging

Nadeeja Wijesekara
Rosemary Ahrens
Ling Wu
Tammy Langman
Anurag Tandon
Paul E. Fraser

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.665348

4,465 views
13 citations

Original Research

Published on 28 Jul 2021

Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Alpna Tyagi
Carol Mirita
Iman Shah
P. Hemachandra Reddy
Subbiah Pugazhenthi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2021.716616

5,764 views
17 citations

Navigation group

Articles

Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node

Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

Mitochondrial Dynamics: A Potential Therapeutic Target for Ischemic Stroke

Efficacy of Δ9 -Tetrahydrocannabinol (THC) Alone or in Combination With a 1:1 Ratio of Cannabidiol (CBD) in Reversing the Spatial Learning Deficits in Old Mice

Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice

Prostaglandin E2 Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases

Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers

Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice

Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen’s Critical Window

Understanding Intra-Species and Inter-Species Prion Conversion and Zoonotic Potential Using Protein Misfolding Cyclic Amplification

In vivo Direct Conversion of Astrocytes to Neurons Maybe a Potential Alternative Strategy for Neurodegenerative Diseases

A Shift in Tissue Stiffness During Hippocampal Maturation Correlates to the Pattern of Neurogenesis and Composition of the Extracellular Matrix

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport

Effects of Lipotoxicity in Brain Microvascular Endothelial Cells During Sirt3 Deficiency-Potential Role in Comorbid Alzheimer’s Disease